Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study

Minesh P. Mehta; Ding Wang; Fen Wang; Lawrence Kleinberg; Anthony Brade; H. Ian Robins; Aruna Turaka; Terri Leahy; Diane Medina; Hao Xiong; Nael M. Mostafa; Martin Dunbar; Ming Zhu; Jane Qian; Kyle Holen; Vincent Giranda; Walter J. Curran

doi:10.1007/s11060-015-1733-1

Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study

Minesh P. Mehta, Ding Wang, Fen Wang, Lawrence Kleinberg, Anthony Brade, H. Ian Robins, Aruna Turaka, Terri Leahy, Diane Medina, Hao Xiong, Nael M. Mostafa, Martin Dunbar, Ming Zhu, Jane Qian, Kyle Holen, Vincent Giranda, Walter J. Curran

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of neuro-oncology
Volume	122
DOIs	https://doi.org/10.1007/s11060-015-1733-1
State	Published - Apr 1 2015

Disciplines

Medicine and Health Sciences
Oncology
Pathology

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Mehta, M. P., Wang, D., Wang, F., Kleinberg, L., Brade, A., Robins, H. I., Turaka, A., Leahy, T., Medina, D., Xiong, H., Mostafa, N. M., Dunbar, M., Zhu, M., Qian, J., Holen, K., Giranda, V., & Curran, W. J. (2015). Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study. Journal of neuro-oncology, 122. https://doi.org/10.1007/s11060-015-1733-1

Mehta, MP, Wang, D, Wang, F, Kleinberg, L, Brade, A, Robins, HI, Turaka, A, Leahy, T, Medina, D, Xiong, H, Mostafa, NM, Dunbar, M, Zhu, M, Qian, J, Holen, K, Giranda, V & Curran, WJ 2015, 'Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study', Journal of neuro-oncology, vol. 122. https://doi.org/10.1007/s11060-015-1733-1

@article{cf8f8d94e87246af9f2a331e09b0cc36,

title = "Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study",

author = "Mehta, \{Minesh P.\} and Ding Wang and Fen Wang and Lawrence Kleinberg and Anthony Brade and Robins, \{H. Ian\} and Aruna Turaka and Terri Leahy and Diane Medina and Hao Xiong and Mostafa, \{Nael M.\} and Martin Dunbar and Ming Zhu and Jane Qian and Kyle Holen and Vincent Giranda and Curran, \{Walter J.\}",

note = "Veliparib, a potent, oral PARP inhibitor, potentiates the antitumor activity of radiation therapy and crosses the blood-brain barrier. This was a phase 1 dose-escalation study evaluating the safety, and secondarily the antitumor activity of veliparib in combination with whole brain radiation therapy (WBRT) in patients with brain metastases, in order to power future trials.",

year = "2015",

month = apr,

day = "1",

doi = "10.1007/s11060-015-1733-1",

language = "American English",

volume = "122",

journal = "Journal of neuro-oncology",

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TY - JOUR

T1 - Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study

AU - Mehta, Minesh P.

AU - Wang, Ding

AU - Wang, Fen

AU - Kleinberg, Lawrence

AU - Brade, Anthony

AU - Robins, H. Ian

AU - Turaka, Aruna

AU - Leahy, Terri

AU - Medina, Diane

AU - Xiong, Hao

AU - Mostafa, Nael M.

AU - Dunbar, Martin

AU - Zhu, Ming

AU - Qian, Jane

AU - Holen, Kyle

AU - Giranda, Vincent

AU - Curran, Walter J.

N1 - Veliparib, a potent, oral PARP inhibitor, potentiates the antitumor activity of radiation therapy and crosses the blood-brain barrier. This was a phase 1 dose-escalation study evaluating the safety, and secondarily the antitumor activity of veliparib in combination with whole brain radiation therapy (WBRT) in patients with brain metastases, in order to power future trials.

PY - 2015/4/1

Y1 - 2015/4/1

UR - https://link.springer.com/content/pdf/10.1007%2Fs11060-015-1733-1.pdf

U2 - 10.1007/s11060-015-1733-1

DO - 10.1007/s11060-015-1733-1

M3 - Article

VL - 122

JO - Journal of neuro-oncology

JF - Journal of neuro-oncology

ER -

Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study

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