Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.

Randy S D'Amico; Justin A Neira; Jonathan Yun; Nikita G Alexiades; Matei Banu; Zachary K Englander; Benjamin C Kennedy; Timothy H Ung; Robert J Rothrock; Alexander Romanov; Xiaotao Guo; Binsheng Zhao; Adam M Sonabend; Peter Canoll; Jeffrey N Bruce

doi:10.3171/2019.3.JNS1963

Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.

Randy S D'Amico, Justin A Neira, Jonathan Yun, Nikita G Alexiades, Matei Banu, Zachary K Englander, Benjamin C Kennedy, Timothy H Ung, Robert J Rothrock, Alexander Romanov, Xiaotao Guo, Binsheng Zhao, Adam M Sonabend, Peter Canoll, Jeffrey N Bruce

Miami Neuroscience Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Neurosurgery
Volume	133
DOIs	https://doi.org/10.3171/2019.3.JNS1963
State	Published - Sep 1 2020

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Medicine and Health Sciences
Anesthesiology

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D'Amico, R. S., Neira, J. A., Yun, J., Alexiades, N. G., Banu, M., Englander, Z. K., Kennedy, B. C., Ung, T. H., Rothrock, R. J., Romanov, A., Guo, X., Zhao, B., Sonabend, A. M., Canoll, P., & Bruce, J. N. (2020). Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model. Journal of Neurosurgery, 133. https://doi.org/10.3171/2019.3.JNS1963

D'Amico, RS, Neira, JA, Yun, J, Alexiades, NG, Banu, M, Englander, ZK, Kennedy, BC, Ung, TH, Rothrock, RJ, Romanov, A, Guo, X, Zhao, B, Sonabend, AM, Canoll, P & Bruce, JN 2020, 'Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.', Journal of Neurosurgery, vol. 133. https://doi.org/10.3171/2019.3.JNS1963

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title = "Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.",

author = "D'Amico, \{Randy S\} and Neira, \{Justin A\} and Jonathan Yun and Alexiades, \{Nikita G\} and Matei Banu and Englander, \{Zachary K\} and Kennedy, \{Benjamin C\} and Ung, \{Timothy H\} and Rothrock, \{Robert J\} and Alexander Romanov and Xiaotao Guo and Binsheng Zhao and Sonabend, \{Adam M\} and Peter Canoll and Bruce, \{Jeffrey N\}",

note = "Prolonged TPT-gadolinium CED via an internalized system is safe and well tolerated and can achieve a large Vdmax, as well as maintain a stable Vd for up to 32 days. Gadolinium provides an identifiable surrogate for measuring drug distribution. Extended CED is potentially a broadly applicable and saf ...",

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doi = "10.3171/2019.3.JNS1963",

language = "American English",

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T1 - Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.

AU - D'Amico, Randy S

AU - Neira, Justin A

AU - Yun, Jonathan

AU - Alexiades, Nikita G

AU - Banu, Matei

AU - Englander, Zachary K

AU - Kennedy, Benjamin C

AU - Ung, Timothy H

AU - Rothrock, Robert J

AU - Romanov, Alexander

AU - Guo, Xiaotao

AU - Zhao, Binsheng

AU - Sonabend, Adam M

AU - Canoll, Peter

AU - Bruce, Jeffrey N

N1 - Prolonged TPT-gadolinium CED via an internalized system is safe and well tolerated and can achieve a large Vdmax, as well as maintain a stable Vd for up to 32 days. Gadolinium provides an identifiable surrogate for measuring drug distribution. Extended CED is potentially a broadly applicable and saf ...

PY - 2020/9/1

Y1 - 2020/9/1

UR - https://pubmed.ncbi.nlm.nih.gov/31374547/

U2 - 10.3171/2019.3.JNS1963

DO - 10.3171/2019.3.JNS1963

M3 - Article

VL - 133

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

ER -

Validation of an effective implantable pump-infusion system for chronic convection-enhanced delivery of intracerebral topotecan in a large animal model.

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