The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline

Laurie E. Gaspar; Minesh P. Mehta; Roy A. Patchell; Stuart H. Burri; Paula D. Robinson; Rachel E. Morris; Mario Ammirati; David W. Andrews; Anthony L. Asher; Charles S. Cobbs; Douglas Kondziolka; Mark E. Linskey; Jay S. Loeffler; Michael McDermott; Tom Mikkelsen; Jeffrey J. Olson; Nina A. Paleologos; Timothy C. Ryken; Steven N. Kalkanis

doi:10.1007/S11060-009-0060-9

The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline

Laurie E. Gaspar
, Minesh P. Mehta
, Roy A. Patchell
, Stuart H. Burri
, Paula D. Robinson
, Rachel E. Morris
, Mario Ammirati
, David W. Andrews
, Anthony L. Asher
, Charles S. Cobbs
, Douglas Kondziolka
, Mark E. Linskey
, Jay S. Loeffler
, Michael McDermott
, Tom Mikkelsen
, Jeffrey J. Olson
, Nina A. Paleologos
, Timothy C. Ryken
, Steven N. Kalkanis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of neuro-oncology
Volume	96
DOIs	https://doi.org/10.1007/S11060-009-0060-9
State	Published - Jan 1 2010

Disciplines

Radiology
Medicine and Health Sciences
Surgery

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10.1007/S11060-009-0060-9License: Unspecified

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Gaspar, L. E., Mehta, M. P., Patchell, R. A., Burri, S. H., Robinson, P. D., Morris, R. E., Ammirati, M., Andrews, D. W., Asher, A. L., Cobbs, C. S., Kondziolka, D., Linskey, M. E., Loeffler, J. S., McDermott, M., Mikkelsen, T., Olson, J. J., Paleologos, N. A., Ryken, T. C., & Kalkanis, S. N. (2010). The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology, 96. https://doi.org/10.1007/S11060-009-0060-9

Gaspar, LE, Mehta, MP, Patchell, RA, Burri, SH, Robinson, PD, Morris, RE, Ammirati, M, Andrews, DW, Asher, AL, Cobbs, CS, Kondziolka, D, Linskey, ME, Loeffler, JS, McDermott, M, Mikkelsen, T, Olson, JJ, Paleologos, NA, Ryken, TC & Kalkanis, SN 2010, 'The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline', Journal of neuro-oncology, vol. 96. https://doi.org/10.1007/S11060-009-0060-9

@article{1c10ec689bf549af983f72e5376c7d5f,

title = "The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline",

author = "Gaspar, \{Laurie E.\} and Mehta, \{Minesh P.\} and Patchell, \{Roy A.\} and Burri, \{Stuart H.\} and Robinson, \{Paula D.\} and Morris, \{Rachel E.\} and Mario Ammirati and Andrews, \{David W.\} and Asher, \{Anthony L.\} and Cobbs, \{Charles S.\} and Douglas Kondziolka and Linskey, \{Mark E.\} and Loeffler, \{Jay S.\} and Michael McDermott and Tom Mikkelsen and Olson, \{Jeffrey J.\} and Paleologos, \{Nina A.\} and Ryken, \{Timothy C.\} and Kalkanis, \{Steven N.\}",

note = "Whole-brain radiation therapy (WBRT) has long been a standard treatment for patients with brain metastases. Based on preclinical and observational data, some physicians alter dose fractionation or withhold WBRT based upon tumor histology. This paper will systematically review the evidence available for altered WBRT dose fractionation and the impact of tumor histopathology on treatment outcomes when WBRT is used.",

year = "2010",

month = jan,

day = "1",

doi = "10.1007/S11060-009-0060-9",

language = "American English",

volume = "96",

journal = "Journal of neuro-oncology",

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TY - JOUR

T1 - The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline

AU - Gaspar, Laurie E.

AU - Mehta, Minesh P.

AU - Patchell, Roy A.

AU - Burri, Stuart H.

AU - Robinson, Paula D.

AU - Morris, Rachel E.

AU - Ammirati, Mario

AU - Andrews, David W.

AU - Asher, Anthony L.

AU - Cobbs, Charles S.

AU - Kondziolka, Douglas

AU - Linskey, Mark E.

AU - Loeffler, Jay S.

AU - McDermott, Michael

AU - Mikkelsen, Tom

AU - Olson, Jeffrey J.

AU - Paleologos, Nina A.

AU - Ryken, Timothy C.

AU - Kalkanis, Steven N.

N1 - Whole-brain radiation therapy (WBRT) has long been a standard treatment for patients with brain metastases. Based on preclinical and observational data, some physicians alter dose fractionation or withhold WBRT based upon tumor histology. This paper will systematically review the evidence available for altered WBRT dose fractionation and the impact of tumor histopathology on treatment outcomes when WBRT is used.

PY - 2010/1/1

Y1 - 2010/1/1

UR - http://europepmc.org/articles/PMC2808517

U2 - 10.1007/S11060-009-0060-9

DO - 10.1007/S11060-009-0060-9

M3 - Article

VL - 96

JO - Journal of neuro-oncology

JF - Journal of neuro-oncology

ER -

The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline

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