Targeting Argininosuccinate Synthetase in Cancer Therapy

Niramol Savaraj; Min You; Chunjing Wu; Macus Tien Kuo; Vy Dinh; Medhi Wangpaichitr; Lynn Feun

doi:10.1007/978-1-4614-0730-0_3

Targeting Argininosuccinate Synthetase in Cancer Therapy

Niramol Savaraj, Min You, Chunjing Wu, Macus Tien Kuo, Vy Dinh, Medhi Wangpaichitr, Lynn Feun

Miami Cancer Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Original language	American English
Title of host publication	Cell Signaling & Molecular Targets in Cancer
DOIs	https://doi.org/10.1007/978-1-4614-0730-0_3
State	Published - Jan 1 2012

Disciplines

Biology
Oncology

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title = "Targeting Argininosuccinate Synthetase in Cancer Therapy",

author = "Niramol Savaraj and Min You and Chunjing Wu and Kuo, \{Macus Tien\} and Vy Dinh and Medhi Wangpaichitr and Lynn Feun",

note = "There has been renewed interest in amino acid deprivation to treat various human cancers. Certain tumors do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. These tumors are auxotrophic for arginine and may be inhibited by arginine deprivation. Arginine deprivation can affect growth and apoptotic signaling.",

year = "2012",

month = jan,

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doi = "10.1007/978-1-4614-0730-0\_3",

language = "American English",

booktitle = "Cell Signaling \& Molecular Targets in Cancer",

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T1 - Targeting Argininosuccinate Synthetase in Cancer Therapy

AU - Savaraj, Niramol

AU - You, Min

AU - Wu, Chunjing

AU - Kuo, Macus Tien

AU - Dinh, Vy

AU - Wangpaichitr, Medhi

AU - Feun, Lynn

N1 - There has been renewed interest in amino acid deprivation to treat various human cancers. Certain tumors do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. These tumors are auxotrophic for arginine and may be inhibited by arginine deprivation. Arginine deprivation can affect growth and apoptotic signaling.

PY - 2012/1/1

Y1 - 2012/1/1

UR - https://link.springer.com/content/pdf/10.1007%2F978-1-4614-0730-0_3.pdf

U2 - 10.1007/978-1-4614-0730-0_3

DO - 10.1007/978-1-4614-0730-0_3

M3 - Chapter

BT - Cell Signaling & Molecular Targets in Cancer

ER -

Targeting Argininosuccinate Synthetase in Cancer Therapy

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