Role of brush border Na+/H+ exchange in canine ileal absorption.

TY - JOUR

T1 - Role of brush border Na+/H+ exchange in canine ileal absorption.

AU - Maher, Michael M.

AU - Gontarek, Jacqueline D.

AU - Jimenez, Ramon E.

AU - Donowitz, Mark

AU - Yeo, Charles J.

N1 - Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology Na+/H+ exchanger isoforms have been identified in mammalian intestinal enterocytes and cloned: NHE1 on the basolateral membrane regulating intracellular pH; and NHE2 and NHE3 on the brush border serving transcellular absorption of Na+, NHE1 and NHE2 are much more sensitive to inhibition by amiloride than NHE3, their in vitro IC 50s for amiloride being 1 μM, 1 μM and 39 μM, respectively.

PY - 1996/4/1

Y1 - 1996/4/1

UR - https://link.springer.com/article/10.1007/BF02213119

U2 - 10.1007/BF02213119

DO - 10.1007/BF02213119

M3 - Article

VL - 41

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

ER -