Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

Miguel-Angel Perales; Jenna D. Goldberg; Jianda Yuan; Guenther Koehne; Lauren Lechner; Esperanza B. Papadopoulos; James W. Young; Ann A. Jakubowski; Bushra Zaidi; Humilidad Gallardo; Cailian Liu; Teresa Rasalan; Jedd D. Wolchok; Therese Croughs; Michel Morre; Sean M. Devlin; Marcel R. M. van den Brink

doi:10.1182/blood-2012-06-437236

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

Miguel-Angel Perales, Jenna D. Goldberg, Jianda Yuan, Guenther Koehne, Lauren Lechner, Esperanza B. Papadopoulos, James W. Young, Ann A. Jakubowski, Bushra Zaidi, Humilidad Gallardo, Cailian Liu, Teresa Rasalan, Jedd D. Wolchok, Therese Croughs, Michel Morre, Sean M. Devlin, Marcel R. M. van den Brink

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Blood
Volume	120
DOIs	https://doi.org/10.1182/blood-2012-06-437236
State	Published - Dec 6 2012

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Biology
Immunology and Infectious Disease

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Perales, M.-A., Goldberg, J. D., Yuan, J., Koehne, G., Lechner, L., Papadopoulos, E. B., Young, J. W., Jakubowski, A. A., Zaidi, B., Gallardo, H., Liu, C., Rasalan, T., Wolchok, J. D., Croughs, T., Morre, M., Devlin, S. M., & van den Brink, M. R. M. (2012). Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood, 120. https://doi.org/10.1182/blood-2012-06-437236

Perales, M-A, Goldberg, JD, Yuan, J, Koehne, G, Lechner, L, Papadopoulos, EB, Young, JW, Jakubowski, AA, Zaidi, B, Gallardo, H, Liu, C, Rasalan, T, Wolchok, JD, Croughs, T, Morre, M, Devlin, SM & van den Brink, MRM 2012, 'Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation', Blood, vol. 120. https://doi.org/10.1182/blood-2012-06-437236

@article{66bc2cb6b3a14c7a80cadf6938697534,

title = "Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation",

author = "Miguel-Angel Perales and Goldberg, {Jenna D.} and Jianda Yuan and Guenther Koehne and Lauren Lechner and Papadopoulos, {Esperanza B.} and Young, {James W.} and Jakubowski, {Ann A.} and Bushra Zaidi and Humilidad Gallardo and Cailian Liu and Teresa Rasalan and Wolchok, {Jedd D.} and Therese Croughs and Michel Morre and Devlin, {Sean M.} and {van den Brink}, {Marcel R. M.}",

note = "Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in T-cell development and survival and enhances immune recovery in murine models of allo-HSCT. We performed a phase 1 trial of r-hIL-7 (CYT107) in recipients of T-cell depleted allo-HSCTs.",

year = "2012",

month = dec,

day = "6",

doi = "10.1182/blood-2012-06-437236",

language = "American English",

volume = "120",

journal = "Blood",

}

TY - JOUR

T1 - Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

AU - Perales, Miguel-Angel

AU - Goldberg, Jenna D.

AU - Yuan, Jianda

AU - Koehne, Guenther

AU - Lechner, Lauren

AU - Papadopoulos, Esperanza B.

AU - Young, James W.

AU - Jakubowski, Ann A.

AU - Zaidi, Bushra

AU - Gallardo, Humilidad

AU - Liu, Cailian

AU - Rasalan, Teresa

AU - Wolchok, Jedd D.

AU - Croughs, Therese

AU - Morre, Michel

AU - Devlin, Sean M.

AU - van den Brink, Marcel R. M.

N1 - Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in T-cell development and survival and enhances immune recovery in murine models of allo-HSCT. We performed a phase 1 trial of r-hIL-7 (CYT107) in recipients of T-cell depleted allo-HSCTs.

PY - 2012/12/6

Y1 - 2012/12/6

UR - http://www.bloodjournal.org/content/120/24/4882?sso-checked=true

U2 - 10.1182/blood-2012-06-437236

DO - 10.1182/blood-2012-06-437236

M3 - Article

VL - 120

JO - Blood

JF - Blood

ER -

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

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