Quantifying risk of radiation necrosis: Normal tissue complication probability modeling following stereotactic radiosurgery for small brain metastases in the modern era

Sreenija Yarlagadda; Ranjini Tolakanahalli; Yanjia Zhang; DJay J. Wieczorek; Tatiana Bejarano; Yongsook C. Lee; Eyub Akdemir; Matthew D. Hall; Robert H. Press; Evan D. Bander; Michael W. McDermott; Alonso N. Gutierrez; Minesh P. Mehta; Rupesh Kotecha

doi:10.1016/j.radonc.2025.111266

Quantifying risk of radiation necrosis: Normal tissue complication probability modeling following stereotactic radiosurgery for small brain metastases in the modern era

Sreenija Yarlagadda
, Ranjini Tolakanahalli
, Yanjia Zhang
, DJay J. Wieczorek
, Tatiana Bejarano
, Yongsook C. Lee
, Eyub Akdemir
, Matthew D. Hall
, Robert H. Press
, Evan D. Bander
, Michael W. McDermott
, Alonso N. Gutierrez
, Minesh P. Mehta
, Rupesh Kotecha

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	111266
Journal	Radiotherapy and Oncology
Volume	214
DOIs	https://doi.org/10.1016/j.radonc.2025.111266
State	Published - Jan 2026

ASJC Scopus Subject Areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

Keywords

Brain metastases
NTCP
Radiation necrosis
SRS

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10.1016/j.radonc.2025.111266

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Yarlagadda, S., Tolakanahalli, R., Zhang, Y., Wieczorek, DJ. J., Bejarano, T., Lee, Y. C., Akdemir, E., Hall, M. D., Press, R. H., Bander, E. D., McDermott, M. W., Gutierrez, A. N., Mehta, M. P., & Kotecha, R. (2026). Quantifying risk of radiation necrosis: Normal tissue complication probability modeling following stereotactic radiosurgery for small brain metastases in the modern era. Radiotherapy and Oncology, 214, Article 111266. https://doi.org/10.1016/j.radonc.2025.111266

Yarlagadda, S, Tolakanahalli, R, Zhang, Y, Wieczorek, DJJ, Bejarano, T, Lee, YC, Akdemir, E, Hall, MD, Press, RH, Bander, ED, McDermott, MW , Gutierrez, AN , Mehta, MP & Kotecha, R 2026, 'Quantifying risk of radiation necrosis: Normal tissue complication probability modeling following stereotactic radiosurgery for small brain metastases in the modern era', Radiotherapy and Oncology, vol. 214, 111266. https://doi.org/10.1016/j.radonc.2025.111266

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title = "Quantifying risk of radiation necrosis: Normal tissue complication probability modeling following stereotactic radiosurgery for small brain metastases in the modern era",

keywords = "Brain metastases, NTCP, Radiation necrosis, SRS",

author = "Sreenija Yarlagadda and Ranjini Tolakanahalli and Yanjia Zhang and Wieczorek, \{DJay J.\} and Tatiana Bejarano and Lee, \{Yongsook C.\} and Eyub Akdemir and Hall, \{Matthew D.\} and Press, \{Robert H.\} and Bander, \{Evan D.\} and McDermott, \{Michael W.\} and Gutierrez, \{Alonso N.\} and Mehta, \{Minesh P.\} and Rupesh Kotecha",

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year = "2026",

month = jan,

doi = "10.1016/j.radonc.2025.111266",

language = "English",

volume = "214",

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AU - Yarlagadda, Sreenija

AU - Tolakanahalli, Ranjini

AU - Zhang, Yanjia

AU - Wieczorek, DJay J.

AU - Bejarano, Tatiana

AU - Lee, Yongsook C.

AU - Akdemir, Eyub

AU - Hall, Matthew D.

AU - Press, Robert H.

AU - Bander, Evan D.

AU - McDermott, Michael W.

AU - Gutierrez, Alonso N.

AU - Mehta, Minesh P.

AU - Kotecha, Rupesh

PY - 2026/1

Y1 - 2026/1

KW - Brain metastases

KW - NTCP

KW - Radiation necrosis

KW - SRS

UR - https://www.scopus.com/pages/publications/105021042598

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U2 - 10.1016/j.radonc.2025.111266

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AN - SCOPUS:105021042598

SN - 0167-8140

VL - 214

JO - Radiotherapy and Oncology

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ER -

Quantifying risk of radiation necrosis: Normal tissue complication probability modeling following stereotactic radiosurgery for small brain metastases in the modern era

ASJC Scopus Subject Areas

Keywords

Access to Document

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