Poor drug distribution as a possible explanation for the results of the PRECISE trial.

John H. Sampson; Gary Archer; Christoph Pedain; Eva Wembacher-Schröder; Manfred Westphal; Sandeep Kunwar; Michael A. Vogelbaum; April Coan; James E. Herndon; Raghu Raghavan; Martin L. Brady; Davi D.A. Reardon; Allan H. Friedman; Henry S. Friedman; M. Inmaculada Rodríguez-Ponce; Susan M. Chang; Stephan Mittermeyer; Davi Croteau; Raj K. Puri; James Mac Dowell Markert; Michael Prados; Thomas Chen; Adam Mamelak; Timothy Cloughesy; John Yu; Kevin Lillehei; Joseph Piepmeier; Edward Pan; Frank Vrionis; H. Lee Moffitt; Jeffrey Olson; James Chandler; Nina Paleologos; Richard W. Byrne; Maciej Lesniak; Jon D. Weingart; Peter Black; Tom Mikkelsen; Joon Uhm; Richard Bucholz; Lauren Abrey; Theodore H. Schwartz; Jeffrey Bruce; Anthony Asher; Stephen Tatter; Gene Barnett; Antonio E. Chiocca; Johnny B. Delashaw; Kevin Judy

doi:10.3171/2009.11.JNS091052

Poor drug distribution as a possible explanation for the results of the PRECISE trial.

John H. Sampson
, Gary Archer
, Christoph Pedain
, Eva Wembacher-Schröder
, Manfred Westphal
, Sandeep Kunwar
, Michael A. Vogelbaum
, April Coan
, James E. Herndon
, Raghu Raghavan
, Martin L. Brady
, Davi D.A. Reardon
, Allan H. Friedman
, Henry S. Friedman
, M. Inmaculada Rodríguez-Ponce
, Susan M. Chang
, Stephan Mittermeyer
, Davi Croteau
, Raj K. Puri
, James Mac Dowell Markert

Michael Prados, Thomas Chen, Adam Mamelak, Timothy Cloughesy, John Yu, Kevin Lillehei, Joseph Piepmeier, Edward Pan, Frank Vrionis, H. Lee Moffitt, Jeffrey Olson, James Chandler, Nina Paleologos, Richard W. Byrne, Maciej Lesniak, Jon D. Weingart, Peter Black, Tom Mikkelsen, Joon Uhm, Richard Bucholz, Lauren Abrey, Theodore H. Schwartz, Jeffrey Bruce, Anthony Asher, Stephen Tatter, Gene Barnett, Antonio E. Chiocca, Johnny B. Delashaw, Kevin Judy

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Neurosurgery
Volume	113
DOIs	https://doi.org/10.3171/2009.11.JNS091052
State	Published - Aug 1 2010

Disciplines

Medicine and Health Sciences
Medical Biophysics
Surgery

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Sampson, J. H., Archer, G., Pedain, C., Wembacher-Schröder, E., Westphal, M., Kunwar, S., Vogelbaum, M. A., Coan, A., Herndon, J. E., Raghavan, R., Brady, M. L., Reardon, D. D. A., Friedman, A. H., Friedman, H. S., Rodríguez-Ponce, M. I., Chang, S. M., Mittermeyer, S., Croteau, D., Puri, R. K., ... Judy, K. (2010). Poor drug distribution as a possible explanation for the results of the PRECISE trial. Journal of Neurosurgery, 113. https://doi.org/10.3171/2009.11.JNS091052

Sampson, JH, Archer, G, Pedain, C, Wembacher-Schröder, E, Westphal, M, Kunwar, S, Vogelbaum, MA, Coan, A, Herndon, JE, Raghavan, R, Brady, ML, Reardon, DDA, Friedman, AH, Friedman, HS, Rodríguez-Ponce, MI, Chang, SM, Mittermeyer, S, Croteau, D, Puri, RK, Markert, JMD, Prados, M, Chen, T, Mamelak, A, Cloughesy, T, Yu, J, Lillehei, K, Piepmeier, J, Pan, E, Vrionis, F, Moffitt, HL, Olson, J, Chandler, J, Paleologos, N, Byrne, RW, Lesniak, M, Weingart, JD, Black, P, Mikkelsen, T, Uhm, J, Bucholz, R, Abrey, L, Schwartz, TH, Bruce, J, Asher, A, Tatter, S, Barnett, G, Chiocca, AE, Delashaw, JB & Judy, K 2010, 'Poor drug distribution as a possible explanation for the results of the PRECISE trial.', Journal of Neurosurgery, vol. 113. https://doi.org/10.3171/2009.11.JNS091052

@article{27b708baf6354ab7a8ebc031f098d9fa,

title = "Poor drug distribution as a possible explanation for the results of the PRECISE trial.",

author = "Sampson, \{John H.\} and Gary Archer and Christoph Pedain and Eva Wembacher-Schr{\"o}der and Manfred Westphal and Sandeep Kunwar and Vogelbaum, \{Michael A.\} and April Coan and Herndon, \{James E.\} and Raghu Raghavan and Brady, \{Martin L.\} and Reardon, \{Davi D.A.\} and Friedman, \{Allan H.\} and Friedman, \{Henry S.\} and Rodr{\'i}guez-Ponce, \{M. Inmaculada\} and Chang, \{Susan M.\} and Stephan Mittermeyer and Davi Croteau and Puri, \{Raj K.\} and Markert, \{James Mac Dowell\} and Michael Prados and Thomas Chen and Adam Mamelak and Timothy Cloughesy and John Yu and Kevin Lillehei and Joseph Piepmeier and Edward Pan and Frank Vrionis and Moffitt, \{H. Lee\} and Jeffrey Olson and James Chandler and Nina Paleologos and Byrne, \{Richard W.\} and Maciej Lesniak and Weingart, \{Jon D.\} and Peter Black and Tom Mikkelsen and Joon Uhm and Richard Bucholz and Lauren Abrey and Schwartz, \{Theodore H.\} and Jeffrey Bruce and Anthony Asher and Stephen Tatter and Gene Barnett and Chiocca, \{Antonio E.\} and Delashaw, \{Johnny B.\} and Kevin Judy",

note = "Object Convection-enhanced delivery (CED) is a novel intracerebral drug delivery technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet clinical end points.",

year = "2010",

month = aug,

day = "1",

doi = "10.3171/2009.11.JNS091052",

language = "American English",

volume = "113",

journal = "Journal of Neurosurgery",

}

TY - JOUR

T1 - Poor drug distribution as a possible explanation for the results of the PRECISE trial.

AU - Sampson, John H.

AU - Archer, Gary

AU - Pedain, Christoph

AU - Wembacher-Schröder, Eva

AU - Westphal, Manfred

AU - Kunwar, Sandeep

AU - Vogelbaum, Michael A.

AU - Coan, April

AU - Herndon, James E.

AU - Raghavan, Raghu

AU - Brady, Martin L.

AU - Reardon, Davi D.A.

AU - Friedman, Allan H.

AU - Friedman, Henry S.

AU - Rodríguez-Ponce, M. Inmaculada

AU - Chang, Susan M.

AU - Mittermeyer, Stephan

AU - Croteau, Davi

AU - Puri, Raj K.

AU - Markert, James Mac Dowell

AU - Prados, Michael

AU - Chen, Thomas

AU - Mamelak, Adam

AU - Cloughesy, Timothy

AU - Yu, John

AU - Lillehei, Kevin

AU - Piepmeier, Joseph

AU - Pan, Edward

AU - Vrionis, Frank

AU - Moffitt, H. Lee

AU - Olson, Jeffrey

AU - Chandler, James

AU - Paleologos, Nina

AU - Byrne, Richard W.

AU - Lesniak, Maciej

AU - Weingart, Jon D.

AU - Black, Peter

AU - Mikkelsen, Tom

AU - Uhm, Joon

AU - Bucholz, Richard

AU - Abrey, Lauren

AU - Schwartz, Theodore H.

AU - Bruce, Jeffrey

AU - Asher, Anthony

AU - Tatter, Stephen

AU - Barnett, Gene

AU - Chiocca, Antonio E.

AU - Delashaw, Johnny B.

AU - Judy, Kevin

N1 - Object Convection-enhanced delivery (CED) is a novel intracerebral drug delivery technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet clinical end points.

PY - 2010/8/1

Y1 - 2010/8/1

UR - https://dx.doi.org/10.3171%2F2009.11.JNS091052

U2 - 10.3171/2009.11.JNS091052

DO - 10.3171/2009.11.JNS091052

M3 - Article

VL - 113

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

ER -

Poor drug distribution as a possible explanation for the results of the PRECISE trial.

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