Polymerase Chain Reaction-Based Microsatellite Analysis of Fine-Needle Aspirations from Hürthle Cell Neoplasms

Yumi Takiyama; Motoyasu Saji; Douglas P. Clark; Grace S. Phillips; Dorry L. Segev; Robert C. Smallridge; William H. Westra; Robert Udelsman; Martha A. Zeiger

doi:10.1089/thy.1997.7.853

Polymerase Chain Reaction-Based Microsatellite Analysis of Fine-Needle Aspirations from Hürthle Cell Neoplasms

Yumi Takiyama, Motoyasu Saji, Douglas P. Clark, Grace S. Phillips, Dorry L. Segev, Robert C. Smallridge, William H. Westra, Robert Udelsman, Martha A. Zeiger

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Thyroid
Volume	7
DOIs	https://doi.org/10.1089/thy.1997.7.853
State	Published - Jan 12 1997
Externally published	Yes

Disciplines

Biology
Pathology
Internal Medicine
Endocrinology

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10.1089/thy.1997.7.853License: Unspecified

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@article{254c6bd075a04b13854cc5557ba9bce2,

title = "Polymerase Chain Reaction-Based Microsatellite Analysis of Fine-Needle Aspirations from H{\"u}rthle Cell Neoplasms",

author = "Yumi Takiyama and Motoyasu Saji and Clark, \{Douglas P.\} and Phillips, \{Grace S.\} and Segev, \{Dorry L.\} and Smallridge, \{Robert C.\} and Westra, \{William H.\} and Robert Udelsman and Zeiger, \{Martha A.\}",

note = "Fine-needle aspiration (FNA) of the thyroid is the sine qua non in the preoperative evaluation of thyroid nodules. Despite this, cytological examination of FNA cannot differentiate malignant from benign Hurthle cell neoplasms. We have previously shown that Hurthle cell carcinomas harbor more genetic alterations on chromosomal arms 1q and 2p than Hurthle cell adenomas, and that all Hurthle cell neoplasms have a significantly higher frequency of alterations on chromosomal arm 1p compared with normal thyroid.",

year = "1997",

month = jan,

day = "12",

doi = "10.1089/thy.1997.7.853",

language = "American English",

volume = "7",

journal = "Thyroid",

}

TY - JOUR

T1 - Polymerase Chain Reaction-Based Microsatellite Analysis of Fine-Needle Aspirations from Hürthle Cell Neoplasms

AU - Takiyama, Yumi

AU - Saji, Motoyasu

AU - Clark, Douglas P.

AU - Phillips, Grace S.

AU - Segev, Dorry L.

AU - Smallridge, Robert C.

AU - Westra, William H.

AU - Udelsman, Robert

AU - Zeiger, Martha A.

N1 - Fine-needle aspiration (FNA) of the thyroid is the sine qua non in the preoperative evaluation of thyroid nodules. Despite this, cytological examination of FNA cannot differentiate malignant from benign Hurthle cell neoplasms. We have previously shown that Hurthle cell carcinomas harbor more genetic alterations on chromosomal arms 1q and 2p than Hurthle cell adenomas, and that all Hurthle cell neoplasms have a significantly higher frequency of alterations on chromosomal arm 1p compared with normal thyroid.

PY - 1997/1/12

Y1 - 1997/1/12

UR - https://mayoclinic.pure.elsevier.com/en/publications/polymerase-chain-reaction-based-microsatellite-analysis-of-fine-n

U2 - 10.1089/thy.1997.7.853

DO - 10.1089/thy.1997.7.853

M3 - Article

VL - 7

JO - Thyroid

JF - Thyroid

ER -

Polymerase Chain Reaction-Based Microsatellite Analysis of Fine-Needle Aspirations from Hürthle Cell Neoplasms

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