Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas

Andrew D. Norden; Andrew D. Norden; David Schiff; Manmeet S. Ahluwalia; Glenn J. Lesser; Lakshmi Nayak; Lakshmi Nayak; Eudocia Q. Lee; Eudocia Q. Lee; Mikael L. Rinne; Mikael L. Rinne; Alona Muzikansky; Jorg Dietrich; Benjamin Purow; Lisa M. Doherty; Debra C. LaFrankie; Julee R. Pulverenti; Jennifer A. Rifenburg; Sandra F. Ruland; Katrina H. Smith; Sarah C. Gaffey; Christine McCluskey; Keith L. Ligon; Keith L. Ligon; David A. Reardon; Patrick Y. Wen; Patrick Y. Wen

doi:10.1007/S11060-014-1631-Y

Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas

Andrew D. Norden
, Andrew D. Norden
, David Schiff
, Manmeet S. Ahluwalia
, Glenn J. Lesser
, Lakshmi Nayak
, Lakshmi Nayak
, Eudocia Q. Lee
, Eudocia Q. Lee
, Mikael L. Rinne
, Mikael L. Rinne
, Alona Muzikansky
, Jorg Dietrich
, Benjamin Purow
, Lisa M. Doherty
, Debra C. LaFrankie
, Julee R. Pulverenti
, Jennifer A. Rifenburg
, Sandra F. Ruland
, Katrina H. Smith

Sarah C. Gaffey, Christine McCluskey, Keith L. Ligon, Keith L. Ligon, David A. Reardon, Patrick Y. Wen, Patrick Y. Wen

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of neuro-oncology
Volume	121
DOIs	https://doi.org/10.1007/S11060-014-1631-Y
State	Published - Jan 1 2015

Disciplines

Medicine and Health Sciences
Oncology
Surgery
Internal Medicine

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Norden, A. D., Norden, A. D., Schiff, D., Ahluwalia, M. S., Lesser, G. J., Nayak, L., Nayak, L., Lee, E. Q., Lee, E. Q., Rinne, M. L., Rinne, M. L., Muzikansky, A., Dietrich, J., Purow, B., Doherty, L. M., LaFrankie, D. C., Pulverenti, J. R., Rifenburg, J. A., Ruland, S. F., ... Wen, P. Y. (2015). Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas. Journal of neuro-oncology, 121. https://doi.org/10.1007/S11060-014-1631-Y

Norden, AD, Norden, AD, Schiff, D, Ahluwalia, MS, Lesser, GJ, Nayak, L, Nayak, L, Lee, EQ, Lee, EQ, Rinne, ML, Rinne, ML, Muzikansky, A, Dietrich, J, Purow, B, Doherty, LM, LaFrankie, DC, Pulverenti, JR, Rifenburg, JA, Ruland, SF, Smith, KH, Gaffey, SC, McCluskey, C, Ligon, KL, Ligon, KL, Reardon, DA, Wen, PY & Wen, PY 2015, 'Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas', Journal of neuro-oncology, vol. 121. https://doi.org/10.1007/S11060-014-1631-Y

@article{44629b30d3b14eb19bf5da72e374cfdd,

title = "Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas",

author = "Norden, \{Andrew D.\} and Norden, \{Andrew D.\} and David Schiff and Ahluwalia, \{Manmeet S.\} and Lesser, \{Glenn J.\} and Lakshmi Nayak and Lakshmi Nayak and Lee, \{Eudocia Q.\} and Lee, \{Eudocia Q.\} and Rinne, \{Mikael L.\} and Rinne, \{Mikael L.\} and Alona Muzikansky and Jorg Dietrich and Benjamin Purow and Doherty, \{Lisa M.\} and LaFrankie, \{Debra C.\} and Pulverenti, \{Julee R.\} and Rifenburg, \{Jennifer A.\} and Ruland, \{Sandra F.\} and Smith, \{Katrina H.\} and Gaffey, \{Sarah C.\} and Christine McCluskey and Ligon, \{Keith L.\} and Ligon, \{Keith L.\} and Reardon, \{David A.\} and Wen, \{Patrick Y.\} and Wen, \{Patrick Y.\}",

note = "Bevacizumab is FDA-approved for patients with recurrent GBM. However, the median duration of response is only 4 months. Potential mechanisms of resistance include upregulated FGF signaling and increased PDGF-mediated pericyte coverage. Nintedanib is an oral, small-molecule tyrosine kinase inhibitor of PDGFR α/β, FGFR 1-3, and VEGFR 1-3 that may overcome resistance to anti-VEGF therapy.",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/S11060-014-1631-Y",

language = "American English",

volume = "121",

journal = "Journal of neuro-oncology",

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TY - JOUR

T1 - Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas

AU - Norden, Andrew D.

AU - Schiff, David

AU - Ahluwalia, Manmeet S.

AU - Lesser, Glenn J.

AU - Nayak, Lakshmi

AU - Lee, Eudocia Q.

AU - Rinne, Mikael L.

AU - Muzikansky, Alona

AU - Dietrich, Jorg

AU - Purow, Benjamin

AU - Doherty, Lisa M.

AU - LaFrankie, Debra C.

AU - Pulverenti, Julee R.

AU - Rifenburg, Jennifer A.

AU - Ruland, Sandra F.

AU - Smith, Katrina H.

AU - Gaffey, Sarah C.

AU - McCluskey, Christine

AU - Ligon, Keith L.

AU - Reardon, David A.

AU - Wen, Patrick Y.

N1 - Bevacizumab is FDA-approved for patients with recurrent GBM. However, the median duration of response is only 4 months. Potential mechanisms of resistance include upregulated FGF signaling and increased PDGF-mediated pericyte coverage. Nintedanib is an oral, small-molecule tyrosine kinase inhibitor of PDGFR α/β, FGFR 1-3, and VEGFR 1-3 that may overcome resistance to anti-VEGF therapy.

PY - 2015/1/1

Y1 - 2015/1/1

UR - https://link.springer.com/article/10.1007/s11060-014-1631-y

U2 - 10.1007/S11060-014-1631-Y

DO - 10.1007/S11060-014-1631-Y

M3 - Article

VL - 121

JO - Journal of neuro-oncology

JF - Journal of neuro-oncology

ER -

Phase II trial of triple tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade gliomas

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