Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh; Petra Houbova; Rudolph J. Castellani; Fausto J. Rodriguez; Minesh P. Mehta; Graeme F. Woodworth

doi:10.1016/j.jocn.2016.01.022

Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh, Petra Houbova, Rudolph J. Castellani, Fausto J. Rodriguez, Minesh P. Mehta, Graeme F. Woodworth

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Clinical Neuroscience
Volume	30
DOIs	https://doi.org/10.1016/j.jocn.2016.01.022
State	Published - Jan 8 2016

Disciplines

Anesthesiology
Medicine and Health Sciences
Pathology
Endocrinology, Diabetes, and Metabolism

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10.1016/j.jocn.2016.01.022License: Unspecified

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@article{e385fb0fe6bd4e55a922f15dd4da6ab4,

title = "Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits",

author = "Hersh, \{David S.\} and Petra Houbova and Castellani, \{Rudolph J.\} and Rodriguez, \{Fausto J.\} and Mehta, \{Minesh P.\} and Woodworth, \{Graeme F.\}",

note = "We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas.",

year = "2016",

month = jan,

day = "8",

doi = "10.1016/j.jocn.2016.01.022",

language = "American English",

volume = "30",

journal = "Journal of Clinical Neuroscience",

}

TY - JOUR

T1 - Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

AU - Hersh, David S.

AU - Houbova, Petra

AU - Castellani, Rudolph J.

AU - Rodriguez, Fausto J.

AU - Mehta, Minesh P.

AU - Woodworth, Graeme F.

N1 - We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas.

PY - 2016/1/8

Y1 - 2016/1/8

UR - https://www.sciencedirect.com/science/article/pii/S0967586816000679

U2 - 10.1016/j.jocn.2016.01.022

DO - 10.1016/j.jocn.2016.01.022

M3 - Article

VL - 30

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -

Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

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