NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933

Joseph Bovi; Stephanie L Pugh; David Sabsevitz; Clifford G Robinson; Eric Paulson; Minesh P Mehta; Vinai Gondi; Vijayananda Kundapur; Wayne H Pinover; Samuel T Chao; Mitch Machtay; Albert S DeNittis; Nadia N Laack; Jeffrey N Greenspoon; Robert S Mannel; Jiayi Huang; Michael M Dominello; Lisa A Kachnic

doi:10.1093/neuonc/nox168.563

NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933

Joseph Bovi
, Stephanie L Pugh
, David Sabsevitz
, Clifford G Robinson
, Eric Paulson
, Minesh P Mehta
, Vinai Gondi
, Vijayananda Kundapur
, Wayne H Pinover
, Samuel T Chao
, Mitch Machtay
, Albert S DeNittis
, Nadia N Laack
, Jeffrey N Greenspoon
, Robert S Mannel
, Jiayi Huang
, Michael M Dominello
, Lisa A Kachnic

Herbert Wertheim Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Neuro-oncology
Volume	19
DOIs	https://doi.org/10.1093/neuonc/nox168.563
State	Published - Nov 6 2017

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Bovi, J., Pugh, S. L., Sabsevitz, D., Robinson, C. G., Paulson, E., Mehta, M. P., Gondi, V., Kundapur, V., Pinover, W. H., Chao, S. T., Machtay, M., DeNittis, A. S., Laack, N. N., Greenspoon, J. N., Mannel, R. S., Huang, J., Dominello, M. M., & Kachnic, L. A. (2017). NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933. Neuro-oncology, 19. https://doi.org/10.1093/neuonc/nox168.563

NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933. / Bovi, Joseph; Pugh, Stephanie L; Sabsevitz, David et al.
In: Neuro-oncology, Vol. 19, 06.11.2017.

Research output: Contribution to journal › Article › peer-review

Bovi, J, Pugh, SL, Sabsevitz, D, Robinson, CG, Paulson, E, Mehta, MP, Gondi, V, Kundapur, V, Pinover, WH, Chao, ST, Machtay, M, DeNittis, AS, Laack, NN, Greenspoon, JN, Mannel, RS, Huang, J, Dominello, MM & Kachnic, LA 2017, 'NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933', Neuro-oncology, vol. 19. https://doi.org/10.1093/neuonc/nox168.563

@article{403bb379e8f04c2a840cdff83ef6968e,

title = "NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933",

author = "Joseph Bovi and Pugh, \{Stephanie L\} and David Sabsevitz and Robinson, \{Clifford G\} and Eric Paulson and Mehta, \{Minesh P\} and Vinai Gondi and Vijayananda Kundapur and Pinover, \{Wayne H\} and Chao, \{Samuel T\} and Mitch Machtay and DeNittis, \{Albert S\} and Laack, \{Nadia N\} and Greenspoon, \{Jeffrey N\} and Mannel, \{Robert S\} and Jiayi Huang and Dominello, \{Michael M\} and Kachnic, \{Lisa A\}",

note = "PURPOSERTOG 0933 demonstrated benefits to memory following HA-WBRT, supporting the hypothesis of hippocampal radiosensitivity and associated memory specificity. However, some patients demonstrated cognitive decline, suggesting mechanisms outside hippocampal radiosensitivity playing a role. WMI has been implicated in RT-induced cognitive decline. This secondary analysis explored the relationship between pre-treatment WMI and memory following HA-WBRT.METHODS113 patients received HA-WBRT.",

year = "2017",

month = nov,

day = "6",

doi = "10.1093/neuonc/nox168.563",

language = "American English",

volume = "19",

journal = "Neuro-oncology",

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T1 - NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933

AU - Bovi, Joseph

AU - Pugh, Stephanie L

AU - Sabsevitz, David

AU - Robinson, Clifford G

AU - Paulson, Eric

AU - Mehta, Minesh P

AU - Gondi, Vinai

AU - Kundapur, Vijayananda

AU - Pinover, Wayne H

AU - Chao, Samuel T

AU - Machtay, Mitch

AU - DeNittis, Albert S

AU - Laack, Nadia N

AU - Greenspoon, Jeffrey N

AU - Mannel, Robert S

AU - Huang, Jiayi

AU - Dominello, Michael M

AU - Kachnic, Lisa A

N1 - PURPOSERTOG 0933 demonstrated benefits to memory following HA-WBRT, supporting the hypothesis of hippocampal radiosensitivity and associated memory specificity. However, some patients demonstrated cognitive decline, suggesting mechanisms outside hippocampal radiosensitivity playing a role. WMI has been implicated in RT-induced cognitive decline. This secondary analysis explored the relationship between pre-treatment WMI and memory following HA-WBRT.METHODS113 patients received HA-WBRT.

PY - 2017/11/6

Y1 - 2017/11/6

UR - http://academic.oup.com/neuro-oncology/article/19/suppl_6/vi137/4590751

U2 - 10.1093/neuonc/nox168.563

DO - 10.1093/neuonc/nox168.563

M3 - Article

VL - 19

JO - Neuro-oncology

JF - Neuro-oncology

ER -

NCOG-02. PRETREATMENT VOLUME OF MRI-DETERMINED WHITE MATTER INJURY (WMI) PREDICTS COGNITIVE DECLINE AFTER HIPPOCAMPAL AVOIDANT (HA) WBRT FOR BRAIN METASTASES: SECONDARY ANALYSIS OF NRG ONCOLOGY RTOG 0933

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