Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)

Laura A. Huppert; Reshma Mahtani; Samantha Fisch; Naomi Dempsey; Sarah Premji; Angelina Raimonde; Saya Jacob; Laura Quintal; Michelle Melisko; Jo Chien; Ana Sandoval; Lauren Carcas; Manmeet Ahluwalia; Natasha Harpalani; Jenna Hoppenworth; Anne Blaes; Kelly Blum; Mi Ok Kim; Dame Idossa; Ruta Rao; Karthik V. Giridhar; Hope S. Rugo

doi:10.1038/s41523-025-00748-5

Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)

Laura A. Huppert
, Reshma Mahtani
, Samantha Fisch
, Naomi Dempsey
, Sarah Premji
, Angelina Raimonde
, Saya Jacob
, Laura Quintal
, Michelle Melisko
, Jo Chien
, Ana Sandoval
, Lauren Carcas
, Manmeet Ahluwalia
, Natasha Harpalani
, Jenna Hoppenworth
, Anne Blaes
, Kelly Blum
, Mi Ok Kim
, Dame Idossa
, Ruta Rao

Karthik V. Giridhar, Hope S. Rugo

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	34
Journal	NPJ breast cancer
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41523-025-00748-5
State	Published - Dec 2025

ASJC Scopus Subject Areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

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10.1038/s41523-025-00748-5

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Huppert, L. A., Mahtani, R., Fisch, S., Dempsey, N., Premji, S., Raimonde, A., Jacob, S., Quintal, L., Melisko, M., Chien, J., Sandoval, A., Carcas, L., Ahluwalia, M., Harpalani, N., Hoppenworth, J., Blaes, A., Blum, K., Kim, M. O., Idossa, D., ... Rugo, H. S. (2025). Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC). NPJ breast cancer, 11(1), Article 34. https://doi.org/10.1038/s41523-025-00748-5

Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC). / Huppert, Laura A.; Mahtani, Reshma; Fisch, Samantha et al.
In: NPJ breast cancer, Vol. 11, No. 1, 34, 12.2025.

Research output: Contribution to journal › Article › peer-review

Huppert, LA, Mahtani, R, Fisch, S, Dempsey, N, Premji, S, Raimonde, A, Jacob, S, Quintal, L, Melisko, M, Chien, J, Sandoval, A, Carcas, L , Ahluwalia, M, Harpalani, N, Hoppenworth, J, Blaes, A, Blum, K, Kim, MO, Idossa, D, Rao, R, Giridhar, KV & Rugo, HS 2025, 'Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)', NPJ breast cancer, vol. 11, no. 1, 34. https://doi.org/10.1038/s41523-025-00748-5

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AU - Huppert, Laura A.

AU - Mahtani, Reshma

AU - Fisch, Samantha

AU - Dempsey, Naomi

AU - Premji, Sarah

AU - Raimonde, Angelina

AU - Jacob, Saya

AU - Quintal, Laura

AU - Melisko, Michelle

AU - Chien, Jo

AU - Sandoval, Ana

AU - Carcas, Lauren

AU - Ahluwalia, Manmeet

AU - Harpalani, Natasha

AU - Hoppenworth, Jenna

AU - Blaes, Anne

AU - Blum, Kelly

AU - Kim, Mi Ok

AU - Idossa, Dame

AU - Rao, Ruta

AU - Giridhar, Karthik V.

AU - Rugo, Hope S.

PY - 2025/12

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Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)

ASJC Scopus Subject Areas

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