TY - JOUR
T1 - Multi-Institutional Analysis of MR-Guided Single-Fraction Stereotactic Ablative Body Radiation Therapy
T2 - Feasibility, Safety, and Efficacy
AU - Fuchs, Frederik
AU - Herrera, Roberto
AU - Kotecha, Rupesh
AU - Rubens, Muni
AU - Roy, Mukesh
AU - Mittauer, Kathryn E
AU - Mansoorian, Sina
AU - Kaiser, Adeel
AU - Kalman, Noah
AU - Gaasch, Aurelie
AU - Marschner, Sebastian N
AU - Bassiri, Nema
AU - Rogowski, Paul
AU - Eze, Chukwuka
AU - Belka, Claus
AU - Corradini, Stefanie
AU - Chuong, Michael D
N1 - Copyright © 2025. Published by Elsevier Inc.
PY - 2025/12/19
Y1 - 2025/12/19
N2 - PURPOSE: Stereotactic ablative body radiation therapy (SABR) is commonly delivered in multiple fractions, whereas single-fraction (SF) SABR remains uncommon. Magnetic resonance (MR) guided linacs provide superior soft-tissue contrast compared to cone-beam computed tomography on conventional linacs, online adaptive replanning, continuous intrafraction visualization, and automatically triggered beam delivery, potentially enabling safe and effective SF-SABR.METHODS AND MATERIALS: We retrospectively analyzed patients treated with MR-guided SF-SABR on a 0.35 Tesla MR-linac at two centers in XXX and XXX (anonymized for review). Median SF-SABR doses were 28 Gy (range: 28-40 Gy) for liver lesions, 30 Gy (range: 28-34 Gy) for lung lesions, 25 Gy for adrenal gland lesions and lymph nodes, and 26 Gy (range: 25-26 Gy) for renal lesions. Endpoints included local control (LC), progression-free survival (PFS), overall survival (OS), and toxicity graded according to CTCAE v5.0.RESULTS: Between April 2020 and December 2024, 161 patients with 175 lesions underwent MR-guided SF-SABR. Lesion distribution was liver (48.0%), lung (42.9%), adrenal gland (4.3%), lymph nodes (3.4%), and kidney (1.9%). Median gross tumor volume (GTV) and planning target volume were 2.4 cc (range: 0.2-83.3 cc) and 9.3 cc (range: 1.4-112.1 cc), respectively. At a median follow-up of 19.3 months, LC rates at 1 and 2 years were 99.1% and 93.6%, respectively. PFS rates at 1 and 2 years were 59.3% and 51.4%, while OS rates were 81.8% and 73.4%, respectively. Treatment was well tolerated, with only one acute grade 3 toxicity reported and no acute grade 4-5 or late grade 3-5 toxicities. Colorectal primary tumors were associated with poorer LC (HR 0.226; p=0.023). Larger GTV independently correlated with reduced LC (HR 1.15; p=0.048) and OS (HR 1.05; p=0.001).CONCLUSIONS: MR-guided SF-SABR is feasible, safe, and effective across various tumor locations, providing favorable LC with minimal toxicity, warranting further prospective evaluation.
AB - PURPOSE: Stereotactic ablative body radiation therapy (SABR) is commonly delivered in multiple fractions, whereas single-fraction (SF) SABR remains uncommon. Magnetic resonance (MR) guided linacs provide superior soft-tissue contrast compared to cone-beam computed tomography on conventional linacs, online adaptive replanning, continuous intrafraction visualization, and automatically triggered beam delivery, potentially enabling safe and effective SF-SABR.METHODS AND MATERIALS: We retrospectively analyzed patients treated with MR-guided SF-SABR on a 0.35 Tesla MR-linac at two centers in XXX and XXX (anonymized for review). Median SF-SABR doses were 28 Gy (range: 28-40 Gy) for liver lesions, 30 Gy (range: 28-34 Gy) for lung lesions, 25 Gy for adrenal gland lesions and lymph nodes, and 26 Gy (range: 25-26 Gy) for renal lesions. Endpoints included local control (LC), progression-free survival (PFS), overall survival (OS), and toxicity graded according to CTCAE v5.0.RESULTS: Between April 2020 and December 2024, 161 patients with 175 lesions underwent MR-guided SF-SABR. Lesion distribution was liver (48.0%), lung (42.9%), adrenal gland (4.3%), lymph nodes (3.4%), and kidney (1.9%). Median gross tumor volume (GTV) and planning target volume were 2.4 cc (range: 0.2-83.3 cc) and 9.3 cc (range: 1.4-112.1 cc), respectively. At a median follow-up of 19.3 months, LC rates at 1 and 2 years were 99.1% and 93.6%, respectively. PFS rates at 1 and 2 years were 59.3% and 51.4%, while OS rates were 81.8% and 73.4%, respectively. Treatment was well tolerated, with only one acute grade 3 toxicity reported and no acute grade 4-5 or late grade 3-5 toxicities. Colorectal primary tumors were associated with poorer LC (HR 0.226; p=0.023). Larger GTV independently correlated with reduced LC (HR 1.15; p=0.048) and OS (HR 1.05; p=0.001).CONCLUSIONS: MR-guided SF-SABR is feasible, safe, and effective across various tumor locations, providing favorable LC with minimal toxicity, warranting further prospective evaluation.
U2 - 10.1016/j.ijrobp.2025.12.018
DO - 10.1016/j.ijrobp.2025.12.018
M3 - Article
C2 - 41422918
SN - 0360-3016
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
ER -