Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer

Michael D Chuong; Jonathan Ashman; Krishan Jethwa; Jordan Kharofa; Hyun Kim; Eugene Koay; Ethan Ludmir; Eric Miller; Bailey Nelson; Marsha Reyngold; Nina Sanford; Daniel Chang

doi:10.1016/j.ijrobp.2025.02.022

Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer

Michael D Chuong, Jonathan Ashman, Krishan Jethwa, Jordan Kharofa, Hyun Kim, Eugene Koay, Ethan Ludmir, Eric Miller, Bailey Nelson, Marsha Reyngold, Nina Sanford, Daniel Chang

Miami Cancer Institute

Research output: Contribution to journal › Review article › peer-review

Abstract

Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC.

Original language	English
Journal	International Journal of Radiation Oncology, Biology, Physics
DOIs	https://doi.org/10.1016/j.ijrobp.2025.02.022
State	E-pub ahead of print - Mar 1 2025

Access to Document

10.1016/j.ijrobp.2025.02.022

Cite this

Chuong, M. D., Ashman, J., Jethwa, K., Kharofa, J., Kim, H., Koay, E., Ludmir, E., Miller, E., Nelson, B., Reyngold, M., Sanford, N., & Chang, D. (2025). Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer. International Journal of Radiation Oncology, Biology, Physics. Advance online publication. https://doi.org/10.1016/j.ijrobp.2025.02.022

Chuong, MD, Ashman, J, Jethwa, K, Kharofa, J, Kim, H, Koay, E, Ludmir, E, Miller, E, Nelson, B, Reyngold, M, Sanford, N & Chang, D 2025, 'Moving From the Background Toward the Spotlight: A Critical Review of Radiation Therapy for Locally Advanced Pancreas Cancer', International Journal of Radiation Oncology, Biology, Physics. https://doi.org/10.1016/j.ijrobp.2025.02.022

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abstract = "Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC.",

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AU - Ashman, Jonathan

AU - Jethwa, Krishan

AU - Kharofa, Jordan

AU - Kim, Hyun

AU - Koay, Eugene

AU - Ludmir, Ethan

AU - Miller, Eric

AU - Nelson, Bailey

AU - Reyngold, Marsha

AU - Sanford, Nina

AU - Chang, Daniel

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AB - Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC.

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DO - 10.1016/j.ijrobp.2025.02.022

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