Intratumoral activity of ONC201 in adult recurrent glioblastoma patients.

Isabel Arrillaga; Yazmin Odia; Joshua E. Allen; Varun V. Prabhu; Rohinton Tarapore; Wolfgang Oster; Minesh P. Mehta; Patrick Y. Wen; Tracy Batchelor

doi:10.1200/JCO.2018.36.15_suppl.e14034

Intratumoral activity of ONC201 in adult recurrent glioblastoma patients.

Isabel Arrillaga, Yazmin Odia, Joshua E. Allen, Varun V. Prabhu, Rohinton Tarapore, Wolfgang Oster, Minesh P. Mehta, Patrick Y. Wen, Tracy Batchelor

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of Clinical Oncology
Volume	36
DOIs	https://doi.org/10.1200/JCO.2018.36.15_suppl.e14034
State	Published - May 20 2018

Disciplines

Medicine and Health Sciences
Pathology
Oncology
Internal Medicine

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@article{822cdf0abadf41d090e07fa1462b2441,

title = "Intratumoral activity of ONC201 in adult recurrent glioblastoma patients.",

author = "Isabel Arrillaga and Yazmin Odia and Allen, {Joshua E.} and Prabhu, {Varun V.} and Rohinton Tarapore and Wolfgang Oster and Mehta, {Minesh P.} and Wen, {Patrick Y.} and Tracy Batchelor",

note = "e14034 Background: ONC201 is an antagonist of the G protein-coupled receptor DRD2 that crosses the blood-brain barrier and induces tumor cell apoptosis in preclinical models. The anti-tumor activity of ONC201 is pronounced in cells with low DRD5 expression and is associated with induction of the ATF4/CHOP/DR5-mediated integrated stress response pathway to trigger apoptosis.",

year = "2018",

month = may,

day = "20",

doi = "10.1200/JCO.2018.36.15_suppl.e14034",

language = "American English",

volume = "36",

journal = "Journal of Clinical Oncology",

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TY - JOUR

T1 - Intratumoral activity of ONC201 in adult recurrent glioblastoma patients.

AU - Arrillaga, Isabel

AU - Odia, Yazmin

AU - Allen, Joshua E.

AU - Prabhu, Varun V.

AU - Tarapore, Rohinton

AU - Oster, Wolfgang

AU - Mehta, Minesh P.

AU - Wen, Patrick Y.

AU - Batchelor, Tracy

N1 - e14034 Background: ONC201 is an antagonist of the G protein-coupled receptor DRD2 that crosses the blood-brain barrier and induces tumor cell apoptosis in preclinical models. The anti-tumor activity of ONC201 is pronounced in cells with low DRD5 expression and is associated with induction of the ATF4/CHOP/DR5-mediated integrated stress response pathway to trigger apoptosis.

PY - 2018/5/20

Y1 - 2018/5/20

UR - https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e14034

U2 - 10.1200/JCO.2018.36.15_suppl.e14034

DO - 10.1200/JCO.2018.36.15_suppl.e14034

M3 - Article

VL - 36

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

ER -

Intratumoral activity of ONC201 in adult recurrent glioblastoma patients.

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