Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan

Núria Lluís; Shunsuke Onoe; Mario Serradilla-Martín; Mar Achalandabaso; Takashi Mizuno; François Jehaes; Bobby V M Dasari; Sara Mambrilla-Herrero; Ernesto Sparrelid; Anita Balakrishnan; Frederik J H Hoogwater; María J Amaral; Bodil Andersson; Frederik Berrevoet; Alexandre Doussot; Víctor López-López; Olivier Detry; Carlos Domingo-Del Pozo; Nikolaos Machairas; Damján Pekli; Cándido F Alcázar-López; Horacio Asbun; Bergthor Björnsson; Thalis Christophides; Alberto Díez-Caballero; David Francart; Colin B Noel; Donzília Sousa-Silva; Enrique Toledo-Martínez; George N Tzimas; Sheraz Yaqub; Junpei Yamaguchi; Safi Dokmak; Mikel Prieto-Calvo; Melroy A D'Souza; Harry V M Spiers; Marius C van den Heuvel; Ramón Charco; Mickaël Lesurtel; Tomoki Ebata; José M Ramia

doi:10.1016/j.hpb.2024.01.009

Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan

Núria Lluís
, Shunsuke Onoe
, Mario Serradilla-Martín
, Mar Achalandabaso
, Takashi Mizuno
, François Jehaes
, Bobby V M Dasari
, Sara Mambrilla-Herrero
, Ernesto Sparrelid
, Anita Balakrishnan
, Frederik J H Hoogwater
, María J Amaral
, Bodil Andersson
, Frederik Berrevoet
, Alexandre Doussot
, Víctor López-López
, Olivier Detry
, Carlos Domingo-Del Pozo
, Nikolaos Machairas
, Damján Pekli

Cándido F Alcázar-López, Horacio Asbun, Bergthor Björnsson, Thalis Christophides, Alberto Díez-Caballero, David Francart, Colin B Noel, Donzília Sousa-Silva, Enrique Toledo-Martínez, George N Tzimas, Sheraz Yaqub, Junpei Yamaguchi, Safi Dokmak, Mikel Prieto-Calvo, Melroy A D'Souza, Harry V M Spiers, Marius C van den Heuvel, Ramón Charco, Mickaël Lesurtel, Tomoki Ebata, José M Ramia

Herbert Wertheim Cancer Institute

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB.

METHODS: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan.

RESULTS: A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23% vs 2%, P < .001), less invasive carcinoma (42% vs 85%, P < .001), and more intrahepatic tumors (52% vs 24%, P < .001) than in Nagoya. Patients in Europe experienced less 90-day grade >3 Clavien-Dindo complications (33% vs 68%, P < .001), but higher 90-day mortality rate (7.0% vs 0%, P = .03). R0 resections (81% vs 82%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions.

DISCUSSION: Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.

Original language	English
Pages (from-to)	565-575
Number of pages	11
Journal	HPB : the official journal of the International Hepato Pancreato Biliary Association
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.hpb.2024.01.009
State	Published - Mar 2024

Keywords

Humans
Male
Aged
Female
Bile Ducts, Intrahepatic/surgery
Retrospective Studies
Japan/epidemiology
Rare Diseases/pathology
Bile Duct Neoplasms/pathology
Bile Ducts/pathology

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10.1016/j.hpb.2024.01.009

Cite this

Lluís, N., Onoe, S., Serradilla-Martín, M., Achalandabaso, M., Mizuno, T., Jehaes, F., Dasari, B. V. M., Mambrilla-Herrero, S., Sparrelid, E., Balakrishnan, A., Hoogwater, F. J. H., Amaral, M. J., Andersson, B., Berrevoet, F., Doussot, A., López-López, V., Detry, O., Pozo, C. D.-D., Machairas, N., ... Ramia, J. M. (2024). Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan. HPB : the official journal of the International Hepato Pancreato Biliary Association, 26(4), 565-575. https://doi.org/10.1016/j.hpb.2024.01.009

Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan. / Lluís, Núria; Onoe, Shunsuke; Serradilla-Martín, Mario et al.
In: HPB : the official journal of the International Hepato Pancreato Biliary Association, Vol. 26, No. 4, 03.2024, p. 565-575.

Research output: Contribution to journal › Article › peer-review

Lluís, N, Onoe, S, Serradilla-Martín, M, Achalandabaso, M, Mizuno, T, Jehaes, F, Dasari, BVM, Mambrilla-Herrero, S, Sparrelid, E, Balakrishnan, A, Hoogwater, FJH, Amaral, MJ, Andersson, B, Berrevoet, F, Doussot, A, López-López, V, Detry, O, Pozo, CD-D, Machairas, N, Pekli, D, Alcázar-López, CF, Asbun, H, Björnsson, B, Christophides, T, Díez-Caballero, A, Francart, D, Noel, CB, Sousa-Silva, D, Toledo-Martínez, E, Tzimas, GN, Yaqub, S, Yamaguchi, J, Dokmak, S, Prieto-Calvo, M, D'Souza, MA, Spiers, HVM, van den Heuvel, MC, Charco, R, Lesurtel, M, Ebata, T & Ramia, JM 2024, 'Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan', HPB : the official journal of the International Hepato Pancreato Biliary Association, vol. 26, no. 4, pp. 565-575. https://doi.org/10.1016/j.hpb.2024.01.009

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title = "Intraductal papillary neoplasms of the bile ducts: a comparative study of a rare disease in Europe and Nagoya, Japan",

abstract = "BACKGROUND: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB.METHODS: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan.RESULTS: A total of 85 patients (51\% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64\% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23\% vs 2\%, P < .001), less invasive carcinoma (42\% vs 85\%, P < .001), and more intrahepatic tumors (52\% vs 24\%, P < .001) than in Nagoya. Patients in Europe experienced less 90-day grade >3 Clavien-Dindo complications (33\% vs 68\%, P < .001), but higher 90-day mortality rate (7.0\% vs 0\%, P = .03). R0 resections (81\% vs 82\%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions.DISCUSSION: Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.",

keywords = "Humans, Male, Aged, Female, Bile Ducts, Intrahepatic/surgery, Retrospective Studies, Japan/epidemiology, Rare Diseases/pathology, Bile Duct Neoplasms/pathology, Bile Ducts/pathology",

author = "N{\'u}ria Llu{\'i}s and Shunsuke Onoe and Mario Serradilla-Mart{\'i}n and Mar Achalandabaso and Takashi Mizuno and Fran{\c c}ois Jehaes and Dasari, \{Bobby V M\} and Sara Mambrilla-Herrero and Ernesto Sparrelid and Anita Balakrishnan and Hoogwater, \{Frederik J H\} and Amaral, \{Mar{\'i}a J\} and Bodil Andersson and Frederik Berrevoet and Alexandre Doussot and V{\'i}ctor L{\'o}pez-L{\'o}pez and Olivier Detry and Pozo, \{Carlos Domingo-Del\} and Nikolaos Machairas and Damj{\'a}n Pekli and Alc{\'a}zar-L{\'o}pez, \{C{\'a}ndido F\} and Horacio Asbun and Bergthor Bj{\"o}rnsson and Thalis Christophides and Alberto D{\'i}ez-Caballero and David Francart and Noel, \{Colin B\} and Donz{\'i}lia Sousa-Silva and Enrique Toledo-Mart{\'i}nez and Tzimas, \{George N\} and Sheraz Yaqub and Junpei Yamaguchi and Safi Dokmak and Mikel Prieto-Calvo and D'Souza, \{Melroy A\} and Spiers, \{Harry V M\} and \{van den Heuvel\}, \{Marius C\} and Ram{\'o}n Charco and Micka{\"e}l Lesurtel and Tomoki Ebata and Ramia, \{Jos{\'e} M\}",

year = "2024",

month = mar,

doi = "10.1016/j.hpb.2024.01.009",

language = "English",

volume = "26",

pages = "565--575",

journal = "HPB : the official journal of the International Hepato Pancreato Biliary Association",

issn = "1365-182X",

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}

TY - JOUR

T1 - Intraductal papillary neoplasms of the bile ducts

T2 - a comparative study of a rare disease in Europe and Nagoya, Japan

AU - Lluís, Núria

AU - Onoe, Shunsuke

AU - Serradilla-Martín, Mario

AU - Achalandabaso, Mar

AU - Mizuno, Takashi

AU - Jehaes, François

AU - Dasari, Bobby V M

AU - Mambrilla-Herrero, Sara

AU - Sparrelid, Ernesto

AU - Balakrishnan, Anita

AU - Hoogwater, Frederik J H

AU - Amaral, María J

AU - Andersson, Bodil

AU - Berrevoet, Frederik

AU - Doussot, Alexandre

AU - López-López, Víctor

AU - Detry, Olivier

AU - Pozo, Carlos Domingo-Del

AU - Machairas, Nikolaos

AU - Pekli, Damján

AU - Alcázar-López, Cándido F

AU - Asbun, Horacio

AU - Björnsson, Bergthor

AU - Christophides, Thalis

AU - Díez-Caballero, Alberto

AU - Francart, David

AU - Noel, Colin B

AU - Sousa-Silva, Donzília

AU - Toledo-Martínez, Enrique

AU - Tzimas, George N

AU - Yaqub, Sheraz

AU - Yamaguchi, Junpei

AU - Dokmak, Safi

AU - Prieto-Calvo, Mikel

AU - D'Souza, Melroy A

AU - Spiers, Harry V M

AU - van den Heuvel, Marius C

AU - Charco, Ramón

AU - Lesurtel, Mickaël

AU - Ebata, Tomoki

AU - Ramia, José M

PY - 2024/3

Y1 - 2024/3

N2 - BACKGROUND: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB.METHODS: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan.RESULTS: A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23% vs 2%, P < .001), less invasive carcinoma (42% vs 85%, P < .001), and more intrahepatic tumors (52% vs 24%, P < .001) than in Nagoya. Patients in Europe experienced less 90-day grade >3 Clavien-Dindo complications (33% vs 68%, P < .001), but higher 90-day mortality rate (7.0% vs 0%, P = .03). R0 resections (81% vs 82%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions.DISCUSSION: Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.

AB - BACKGROUND: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB.METHODS: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan.RESULTS: A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23% vs 2%, P < .001), less invasive carcinoma (42% vs 85%, P < .001), and more intrahepatic tumors (52% vs 24%, P < .001) than in Nagoya. Patients in Europe experienced less 90-day grade >3 Clavien-Dindo complications (33% vs 68%, P < .001), but higher 90-day mortality rate (7.0% vs 0%, P = .03). R0 resections (81% vs 82%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions.DISCUSSION: Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Bile Ducts, Intrahepatic/surgery

KW - Retrospective Studies

KW - Japan/epidemiology

KW - Rare Diseases/pathology

KW - Bile Duct Neoplasms/pathology

KW - Bile Ducts/pathology

U2 - 10.1016/j.hpb.2024.01.009

DO - 10.1016/j.hpb.2024.01.009

M3 - Article

C2 - 38307773

SN - 1365-182X

VL - 26

SP - 565

EP - 575

JO - HPB : the official journal of the International Hepato Pancreato Biliary Association

JF - HPB : the official journal of the International Hepato Pancreato Biliary Association

IS - 4

ER -