Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

Brian M. Alexander; Brian M. Alexander; Lorenzo Trippa; Sarah Gaffey; Isabel C. Arrillaga-Romany; Eudocia Q. Lee; Mikael L. Rinne; Mikael L. Rinne; Manmeet S. Ahluwalia; Howard Colman; Geoffrey Fell; Evanthia Galanis; John de Groot; Jan Drappatz; Andrew B. Lassman; David M. Meredith; David M. Meredith; L. Burt Nabors; Sandro Santagata; Sandro Santagata; David Schiff; Mary R. Welch; Keith L. Ligon; Keith L. Ligon; Patrick Y. Wen

doi:10.1200/PO.18.00071

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

Brian M. Alexander
, Brian M. Alexander
, Lorenzo Trippa
, Sarah Gaffey
, Isabel C. Arrillaga-Romany
, Eudocia Q. Lee
, Mikael L. Rinne
, Mikael L. Rinne
, Manmeet S. Ahluwalia
, Howard Colman
, Geoffrey Fell
, Evanthia Galanis
, John de Groot
, Jan Drappatz
, Andrew B. Lassman
, David M. Meredith
, David M. Meredith
, L. Burt Nabors
, Sandro Santagata
, Sandro Santagata

David Schiff, Mary R. Welch, Keith L. Ligon, Keith L. Ligon, Patrick Y. Wen

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	JCO Precision Oncology
Volume	3
DOIs	https://doi.org/10.1200/PO.18.00071
State	Published - Mar 27 2019

Disciplines

Medicine and Health Sciences
Oncology
Internal Medicine

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Alexander, B. M., Alexander, B. M., Trippa, L., Gaffey, S., Arrillaga-Romany, I. C., Lee, E. Q., Rinne, M. L., Rinne, M. L., Ahluwalia, M. S., Colman, H., Fell, G., Galanis, E., de Groot, J., Drappatz, J., Lassman, A. B., Meredith, D. M., Meredith, D. M., Nabors, L. B., Santagata, S., ... Wen, P. Y. (2019). Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma. JCO Precision Oncology, 3. https://doi.org/10.1200/PO.18.00071

Alexander, BM, Alexander, BM, Trippa, L, Gaffey, S, Arrillaga-Romany, IC, Lee, EQ, Rinne, ML, Rinne, ML, Ahluwalia, MS, Colman, H, Fell, G, Galanis, E, de Groot, J, Drappatz, J, Lassman, AB, Meredith, DM, Meredith, DM, Nabors, LB, Santagata, S, Santagata, S, Schiff, D, Welch, MR, Ligon, KL, Ligon, KL & Wen, PY 2019, 'Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.', JCO Precision Oncology, vol. 3. https://doi.org/10.1200/PO.18.00071

@article{84fb39acd83f46a2bd1c0019caf2a059,

title = "Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.",

author = "Alexander, \{Brian M.\} and Alexander, \{Brian M.\} and Lorenzo Trippa and Sarah Gaffey and Arrillaga-Romany, \{Isabel C.\} and Lee, \{Eudocia Q.\} and Rinne, \{Mikael L.\} and Rinne, \{Mikael L.\} and Ahluwalia, \{Manmeet S.\} and Howard Colman and Geoffrey Fell and Evanthia Galanis and \{de Groot\}, John and Jan Drappatz and Lassman, \{Andrew B.\} and Meredith, \{David M.\} and Meredith, \{David M.\} and Nabors, \{L. Burt\} and Sandro Santagata and Sandro Santagata and David Schiff and Welch, \{Mary R.\} and Ligon, \{Keith L.\} and Ligon, \{Keith L.\} and Wen, \{Patrick Y.\}",

note = "PURPOSE Adequately prioritizing the numerous therapies and biomarkers available in late-stage testing for patients with glioblastoma (GBM) requires an efficient clinical testing platform. We developed and implemented INSIGhT (Individualized Screening Trial of Innovative Glioblastoma Therapy) as a novel adaptive platform trial (APT) to develop precision medicine approaches in GBM.",

year = "2019",

month = mar,

day = "27",

doi = "10.1200/PO.18.00071",

language = "American English",

volume = "3",

journal = "JCO Precision Oncology",

}

TY - JOUR

T1 - Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

AU - Alexander, Brian M.

AU - Trippa, Lorenzo

AU - Gaffey, Sarah

AU - Arrillaga-Romany, Isabel C.

AU - Lee, Eudocia Q.

AU - Rinne, Mikael L.

AU - Ahluwalia, Manmeet S.

AU - Colman, Howard

AU - Fell, Geoffrey

AU - Galanis, Evanthia

AU - de Groot, John

AU - Drappatz, Jan

AU - Lassman, Andrew B.

AU - Meredith, David M.

AU - Nabors, L. Burt

AU - Santagata, Sandro

AU - Schiff, David

AU - Welch, Mary R.

AU - Ligon, Keith L.

AU - Wen, Patrick Y.

N1 - PURPOSE Adequately prioritizing the numerous therapies and biomarkers available in late-stage testing for patients with glioblastoma (GBM) requires an efficient clinical testing platform. We developed and implemented INSIGhT (Individualized Screening Trial of Innovative Glioblastoma Therapy) as a novel adaptive platform trial (APT) to develop precision medicine approaches in GBM.

PY - 2019/3/27

Y1 - 2019/3/27

UR - https://ascopubs.org/doi/10.1200/PO.18.00071

U2 - 10.1200/PO.18.00071

DO - 10.1200/PO.18.00071

M3 - Article

VL - 3

JO - JCO Precision Oncology

JF - JCO Precision Oncology

ER -

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

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