Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

Brian M. Alexander; Brian M. Alexander; Lorenzo Trippa; Sarah Gaffey; Isabel C. Arrillaga-Romany; Eudocia Q. Lee; Mikael L. Rinne; Mikael L. Rinne; Manmeet S. Ahluwalia; Howard Colman; Geoffrey Fell; Evanthia Galanis; John de Groot; Jan Drappatz; Andrew B. Lassman; David M. Meredith; David M. Meredith; L. Burt Nabors; Sandro Santagata; Sandro Santagata; David Schiff; Mary R. Welch; Keith L. Ligon; Keith L. Ligon; Patrick Y. Wen

doi:10.1200/PO.18.00071

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

Brian M. Alexander, Brian M. Alexander, Lorenzo Trippa, Sarah Gaffey, Isabel C. Arrillaga-Romany, Eudocia Q. Lee, Mikael L. Rinne, Mikael L. Rinne, Manmeet S. Ahluwalia, Howard Colman, Geoffrey Fell, Evanthia Galanis, John de Groot, Jan Drappatz, Andrew B. Lassman, David M. Meredith, David M. Meredith, L. Burt Nabors, Sandro Santagata, Sandro SantagataDavid Schiff, Mary R. Welch, Keith L. Ligon, Keith L. Ligon, Patrick Y. Wen

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	JCO Precision Oncology
Volume	3
DOIs	https://doi.org/10.1200/PO.18.00071
State	Published - Mar 27 2019

Disciplines

Medicine and Health Sciences
Oncology
Internal Medicine

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Alexander, B. M., Alexander, B. M., Trippa, L., Gaffey, S., Arrillaga-Romany, I. C., Lee, E. Q., Rinne, M. L., Rinne, M. L., Ahluwalia, M. S., Colman, H., Fell, G., Galanis, E., de Groot, J., Drappatz, J., Lassman, A. B., Meredith, D. M., Meredith, D. M., Nabors, L. B., Santagata, S., ... Wen, P. Y. (2019). Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma. JCO Precision Oncology, 3. https://doi.org/10.1200/PO.18.00071

Alexander, BM, Alexander, BM, Trippa, L, Gaffey, S, Arrillaga-Romany, IC, Lee, EQ, Rinne, ML, Rinne, ML, Ahluwalia, MS, Colman, H, Fell, G, Galanis, E, de Groot, J, Drappatz, J, Lassman, AB, Meredith, DM, Meredith, DM, Nabors, LB, Santagata, S, Santagata, S, Schiff, D, Welch, MR, Ligon, KL, Ligon, KL & Wen, PY 2019, 'Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.', JCO Precision Oncology, vol. 3. https://doi.org/10.1200/PO.18.00071

@article{84fb39acd83f46a2bd1c0019caf2a059,

title = "Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.",

author = "Alexander, {Brian M.} and Alexander, {Brian M.} and Lorenzo Trippa and Sarah Gaffey and Arrillaga-Romany, {Isabel C.} and Lee, {Eudocia Q.} and Rinne, {Mikael L.} and Rinne, {Mikael L.} and Ahluwalia, {Manmeet S.} and Howard Colman and Geoffrey Fell and Evanthia Galanis and {de Groot}, John and Jan Drappatz and Lassman, {Andrew B.} and Meredith, {David M.} and Meredith, {David M.} and Nabors, {L. Burt} and Sandro Santagata and Sandro Santagata and David Schiff and Welch, {Mary R.} and Ligon, {Keith L.} and Ligon, {Keith L.} and Wen, {Patrick Y.}",

note = "PURPOSE Adequately prioritizing the numerous therapies and biomarkers available in late-stage testing for patients with glioblastoma (GBM) requires an efficient clinical testing platform. We developed and implemented INSIGhT (Individualized Screening Trial of Innovative Glioblastoma Therapy) as a novel adaptive platform trial (APT) to develop precision medicine approaches in GBM.",

year = "2019",

month = mar,

day = "27",

doi = "10.1200/PO.18.00071",

language = "American English",

volume = "3",

journal = "JCO Precision Oncology",

}

TY - JOUR

T1 - Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

AU - Alexander, Brian M.

AU - Trippa, Lorenzo

AU - Gaffey, Sarah

AU - Arrillaga-Romany, Isabel C.

AU - Lee, Eudocia Q.

AU - Rinne, Mikael L.

AU - Ahluwalia, Manmeet S.

AU - Colman, Howard

AU - Fell, Geoffrey

AU - Galanis, Evanthia

AU - de Groot, John

AU - Drappatz, Jan

AU - Lassman, Andrew B.

AU - Meredith, David M.

AU - Nabors, L. Burt

AU - Santagata, Sandro

AU - Schiff, David

AU - Welch, Mary R.

AU - Ligon, Keith L.

AU - Wen, Patrick Y.

N1 - PURPOSE Adequately prioritizing the numerous therapies and biomarkers available in late-stage testing for patients with glioblastoma (GBM) requires an efficient clinical testing platform. We developed and implemented INSIGhT (Individualized Screening Trial of Innovative Glioblastoma Therapy) as a novel adaptive platform trial (APT) to develop precision medicine approaches in GBM.

PY - 2019/3/27

Y1 - 2019/3/27

UR - https://ascopubs.org/doi/10.1200/PO.18.00071

U2 - 10.1200/PO.18.00071

DO - 10.1200/PO.18.00071

M3 - Article

VL - 3

JO - JCO Precision Oncology

JF - JCO Precision Oncology

ER -

Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma.

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