Increased body mass index is a risk factor for acute promyelocytic leukemia

Sarah M Kashanian; Andrew Y Li; Moaath Mustafa Ali; Mark E Sutherland; Vu H Duong; Bryan C Hambley; Kyle Zacholski; Firas El Chaer; Noa G Holtzman; Mohammad Imran; Ciera L Patzke; Jonathan Cornu; Alison Duffy; Amy E Dezern; Ivana Gojo; Kelly J Norsworthy; Mark J Levis; B Douglas Smith; Maria R Baer; Gabriel Ghiaur; Ashkan Emadi

doi:10.1002/jha2.163

Increased body mass index is a risk factor for acute promyelocytic leukemia

Sarah M Kashanian
, Andrew Y Li
, Moaath Mustafa Ali
, Mark E Sutherland
, Vu H Duong
, Bryan C Hambley
, Kyle Zacholski
, Firas El Chaer
, Noa G Holtzman
, Mohammad Imran
, Ciera L Patzke
, Jonathan Cornu
, Alison Duffy
, Amy E Dezern
, Ivana Gojo
, Kelly J Norsworthy
, Mark J Levis
, B Douglas Smith
, Maria R Baer
, Gabriel Ghiaur

Ashkan Emadi

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Obesity has become increasingly prevalent worldwide and is a risk factor for many malignancies. We studied the correlation between body mass index (BMI) and the incidence of acute promyelocytic leukemia (APL), non-APL acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and control hospitalized patients without leukemia in the same community.

METHODS: Multi-center, retrospective analysis of 71,196 patients: APL (n=200), AML (n=437), ALL (n=103), non-leukemia hospitalized (n=70,456) admitted to University of Maryland and Johns Hopkins Cancer Centers, and University of Maryland Medical Center.

RESULTS: Patients with APL had a significantly higher unadjusted mean and median BMI (32.5 kg/m2 and 30.3 kg/m2) than those with AML (28.3 kg/m2 and 27.1 kg/m2), ALL (29.3 kg/m2 and 27.7 kg/m2), and others (29.3 kg/m2 and 27.7 kg/m2) (p<0.001). Log-transformed BMI multivariable models demonstrated that APL patients had a significantly higher adjusted mean BMI by 3.7 kg/m2 (p<0.001) or approximately 10% (p<0.01) compared to the other groups, when controlled for sex, race, and age.

CONCLUSIONS: This study confirms that when controlled for sex, age, and race there is an independent association of higher BMI among patients with APL compared to patients with ALL, AML, and hospitalized individuals without leukemia in the same community.

Original language	English
Pages (from-to)	33-39
Number of pages	7
Journal	EJHaem
Volume	2
Issue number	1
DOIs	https://doi.org/10.1002/jha2.163
State	Published - Feb 2021
Externally published	Yes

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10.1002/jha2.163

Cite this

Kashanian, S. M., Li, A. Y., Mustafa Ali, M., Sutherland, M. E., Duong, V. H., Hambley, B. C., Zacholski, K., El Chaer, F., Holtzman, N. G., Imran, M., Patzke, C. L., Cornu, J., Duffy, A., Dezern, A. E., Gojo, I., Norsworthy, K. J., Levis, M. J., Smith, B. D., Baer, M. R., ... Emadi, A. (2021). Increased body mass index is a risk factor for acute promyelocytic leukemia. EJHaem, 2(1), 33-39. https://doi.org/10.1002/jha2.163

Kashanian, SM, Li, AY, Mustafa Ali, M, Sutherland, ME, Duong, VH, Hambley, BC, Zacholski, K, El Chaer, F, Holtzman, NG, Imran, M, Patzke, CL, Cornu, J, Duffy, A, Dezern, AE, Gojo, I, Norsworthy, KJ, Levis, MJ, Smith, BD, Baer, MR, Ghiaur, G & Emadi, A 2021, 'Increased body mass index is a risk factor for acute promyelocytic leukemia', EJHaem, vol. 2, no. 1, pp. 33-39. https://doi.org/10.1002/jha2.163

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title = "Increased body mass index is a risk factor for acute promyelocytic leukemia",

abstract = "INTRODUCTION: Obesity has become increasingly prevalent worldwide and is a risk factor for many malignancies. We studied the correlation between body mass index (BMI) and the incidence of acute promyelocytic leukemia (APL), non-APL acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and control hospitalized patients without leukemia in the same community.METHODS: Multi-center, retrospective analysis of 71,196 patients: APL (n=200), AML (n=437), ALL (n=103), non-leukemia hospitalized (n=70,456) admitted to University of Maryland and Johns Hopkins Cancer Centers, and University of Maryland Medical Center.RESULTS: Patients with APL had a significantly higher unadjusted mean and median BMI (32.5 kg/m2 and 30.3 kg/m2) than those with AML (28.3 kg/m2 and 27.1 kg/m2), ALL (29.3 kg/m2 and 27.7 kg/m2), and others (29.3 kg/m2 and 27.7 kg/m2) (p<0.001). Log-transformed BMI multivariable models demonstrated that APL patients had a significantly higher adjusted mean BMI by 3.7 kg/m2 (p<0.001) or approximately 10\% (p<0.01) compared to the other groups, when controlled for sex, race, and age.CONCLUSIONS: This study confirms that when controlled for sex, age, and race there is an independent association of higher BMI among patients with APL compared to patients with ALL, AML, and hospitalized individuals without leukemia in the same community.",

author = "Kashanian, \{Sarah M\} and Li, \{Andrew Y\} and \{Mustafa Ali\}, Moaath and Sutherland, \{Mark E\} and Duong, \{Vu H\} and Hambley, \{Bryan C\} and Kyle Zacholski and \{El Chaer\}, Firas and Holtzman, \{Noa G\} and Mohammad Imran and Patzke, \{Ciera L\} and Jonathan Cornu and Alison Duffy and Dezern, \{Amy E\} and Ivana Gojo and Norsworthy, \{Kelly J\} and Levis, \{Mark J\} and Smith, \{B Douglas\} and Baer, \{Maria R\} and Gabriel Ghiaur and Ashkan Emadi",

year = "2021",

month = feb,

doi = "10.1002/jha2.163",

language = "English",

volume = "2",

pages = "33--39",

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T1 - Increased body mass index is a risk factor for acute promyelocytic leukemia

AU - Kashanian, Sarah M

AU - Li, Andrew Y

AU - Mustafa Ali, Moaath

AU - Sutherland, Mark E

AU - Duong, Vu H

AU - Hambley, Bryan C

AU - Zacholski, Kyle

AU - El Chaer, Firas

AU - Holtzman, Noa G

AU - Imran, Mohammad

AU - Patzke, Ciera L

AU - Cornu, Jonathan

AU - Duffy, Alison

AU - Dezern, Amy E

AU - Gojo, Ivana

AU - Norsworthy, Kelly J

AU - Levis, Mark J

AU - Smith, B Douglas

AU - Baer, Maria R

AU - Ghiaur, Gabriel

AU - Emadi, Ashkan

PY - 2021/2

Y1 - 2021/2

N2 - INTRODUCTION: Obesity has become increasingly prevalent worldwide and is a risk factor for many malignancies. We studied the correlation between body mass index (BMI) and the incidence of acute promyelocytic leukemia (APL), non-APL acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and control hospitalized patients without leukemia in the same community.METHODS: Multi-center, retrospective analysis of 71,196 patients: APL (n=200), AML (n=437), ALL (n=103), non-leukemia hospitalized (n=70,456) admitted to University of Maryland and Johns Hopkins Cancer Centers, and University of Maryland Medical Center.RESULTS: Patients with APL had a significantly higher unadjusted mean and median BMI (32.5 kg/m2 and 30.3 kg/m2) than those with AML (28.3 kg/m2 and 27.1 kg/m2), ALL (29.3 kg/m2 and 27.7 kg/m2), and others (29.3 kg/m2 and 27.7 kg/m2) (p<0.001). Log-transformed BMI multivariable models demonstrated that APL patients had a significantly higher adjusted mean BMI by 3.7 kg/m2 (p<0.001) or approximately 10% (p<0.01) compared to the other groups, when controlled for sex, race, and age.CONCLUSIONS: This study confirms that when controlled for sex, age, and race there is an independent association of higher BMI among patients with APL compared to patients with ALL, AML, and hospitalized individuals without leukemia in the same community.

AB - INTRODUCTION: Obesity has become increasingly prevalent worldwide and is a risk factor for many malignancies. We studied the correlation between body mass index (BMI) and the incidence of acute promyelocytic leukemia (APL), non-APL acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and control hospitalized patients without leukemia in the same community.METHODS: Multi-center, retrospective analysis of 71,196 patients: APL (n=200), AML (n=437), ALL (n=103), non-leukemia hospitalized (n=70,456) admitted to University of Maryland and Johns Hopkins Cancer Centers, and University of Maryland Medical Center.RESULTS: Patients with APL had a significantly higher unadjusted mean and median BMI (32.5 kg/m2 and 30.3 kg/m2) than those with AML (28.3 kg/m2 and 27.1 kg/m2), ALL (29.3 kg/m2 and 27.7 kg/m2), and others (29.3 kg/m2 and 27.7 kg/m2) (p<0.001). Log-transformed BMI multivariable models demonstrated that APL patients had a significantly higher adjusted mean BMI by 3.7 kg/m2 (p<0.001) or approximately 10% (p<0.01) compared to the other groups, when controlled for sex, race, and age.CONCLUSIONS: This study confirms that when controlled for sex, age, and race there is an independent association of higher BMI among patients with APL compared to patients with ALL, AML, and hospitalized individuals without leukemia in the same community.

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DO - 10.1002/jha2.163

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