Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone

Eyub Y Akdemir; Joseph DiStefano; Kevin J Abrams; Charif Sidani; Margaret C Chaneles; Matthew D Hall; Robert H Press; DJay Wieczorek; Ranjini Tolakanahalli; Alonso N Gutierrez; Michael W McDermott; Yazmin Odia; Minesh P Mehta; Rupesh Kotecha

doi:10.1016/j.radonc.2025.111172

Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone

Eyub Y Akdemir
, Joseph DiStefano
, Kevin J Abrams
, Charif Sidani
, Margaret C Chaneles
, Matthew D Hall
, Robert H Press
, DJay Wieczorek
, Ranjini Tolakanahalli
, Alonso N Gutierrez
, Michael W McDermott
, Yazmin Odia
, Minesh P Mehta
, Rupesh Kotecha

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluates the clinical utility of 3D turbo spin echo (3D-TSE) imaging in stereotactic radiosurgery (SRS) planning for brain metastases, examining the value of adding 3D-TSE to MPRAGE. Dual-sequence MRI (MPRAGE + 3D-TSE) significantly prolonged time to distant intracranial failure (DIF) in whole brain radiotherapy (WBRT)-naïve patients (n = 308, 11.4 vs. 6.8 months, p = 0.03), but not in patients previously treated with WBRT and salvaged with SRS (n = 39, 6.5 vs. 5.6 months, p = 0.76). Additional lesion detection attributed to 3D-TSE imaging was greater in WBRT-naïve (19.6 %) than in post-WBRT patients (12.0 %) (p < 0.001). The dual-sequence imaging may improve time to distant failure in the modern era for most patients treated with primary stereotactic radiosurgery and should be integrated into the SRS workflow.

Original language	English
Pages (from-to)	111172
Journal	Radiotherapy and Oncology
DOIs	https://doi.org/10.1016/j.radonc.2025.111172
State	E-pub ahead of print - Sep 28 2025

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10.1016/j.radonc.2025.111172

Cite this

Akdemir, E. Y., DiStefano, J., Abrams, K. J., Sidani, C., Chaneles, M. C., Hall, M. D., Press, R. H., Wieczorek, DJ., Tolakanahalli, R., Gutierrez, A. N., McDermott, M. W., Odia, Y., Mehta, M. P., & Kotecha, R. (2025). Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone. Radiotherapy and Oncology, 111172. Advance online publication. https://doi.org/10.1016/j.radonc.2025.111172

@article{ed19e0555bb84c969c616225678e2a0c,

title = "Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone",

abstract = "This study evaluates the clinical utility of 3D turbo spin echo (3D-TSE) imaging in stereotactic radiosurgery (SRS) planning for brain metastases, examining the value of adding 3D-TSE to MPRAGE. Dual-sequence MRI (MPRAGE + 3D-TSE) significantly prolonged time to distant intracranial failure (DIF) in whole brain radiotherapy (WBRT)-na{\"i}ve patients (n = 308, 11.4 vs. 6.8 months, p = 0.03), but not in patients previously treated with WBRT and salvaged with SRS (n = 39, 6.5 vs. 5.6 months, p = 0.76). Additional lesion detection attributed to 3D-TSE imaging was greater in WBRT-na{\"i}ve (19.6 \%) than in post-WBRT patients (12.0 \%) (p < 0.001). The dual-sequence imaging may improve time to distant failure in the modern era for most patients treated with primary stereotactic radiosurgery and should be integrated into the SRS workflow.",

author = "Akdemir, \{Eyub Y\} and Joseph DiStefano and Abrams, \{Kevin J\} and Charif Sidani and Chaneles, \{Margaret C\} and Hall, \{Matthew D\} and Press, \{Robert H\} and DJay Wieczorek and Ranjini Tolakanahalli and Gutierrez, \{Alonso N\} and McDermott, \{Michael W\} and Yazmin Odia and Mehta, \{Minesh P\} and Rupesh Kotecha",

note = "Copyright {\textcopyright} 2025. Published by Elsevier B.V.",

year = "2025",

month = sep,

day = "28",

doi = "10.1016/j.radonc.2025.111172",

language = "English",

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T1 - Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone

AU - Akdemir, Eyub Y

AU - DiStefano, Joseph

AU - Abrams, Kevin J

AU - Sidani, Charif

AU - Chaneles, Margaret C

AU - Hall, Matthew D

AU - Press, Robert H

AU - Wieczorek, DJay

AU - Tolakanahalli, Ranjini

AU - Gutierrez, Alonso N

AU - McDermott, Michael W

AU - Odia, Yazmin

AU - Mehta, Minesh P

AU - Kotecha, Rupesh

PY - 2025/9/28

Y1 - 2025/9/28

N2 - This study evaluates the clinical utility of 3D turbo spin echo (3D-TSE) imaging in stereotactic radiosurgery (SRS) planning for brain metastases, examining the value of adding 3D-TSE to MPRAGE. Dual-sequence MRI (MPRAGE + 3D-TSE) significantly prolonged time to distant intracranial failure (DIF) in whole brain radiotherapy (WBRT)-naïve patients (n = 308, 11.4 vs. 6.8 months, p = 0.03), but not in patients previously treated with WBRT and salvaged with SRS (n = 39, 6.5 vs. 5.6 months, p = 0.76). Additional lesion detection attributed to 3D-TSE imaging was greater in WBRT-naïve (19.6 %) than in post-WBRT patients (12.0 %) (p < 0.001). The dual-sequence imaging may improve time to distant failure in the modern era for most patients treated with primary stereotactic radiosurgery and should be integrated into the SRS workflow.

AB - This study evaluates the clinical utility of 3D turbo spin echo (3D-TSE) imaging in stereotactic radiosurgery (SRS) planning for brain metastases, examining the value of adding 3D-TSE to MPRAGE. Dual-sequence MRI (MPRAGE + 3D-TSE) significantly prolonged time to distant intracranial failure (DIF) in whole brain radiotherapy (WBRT)-naïve patients (n = 308, 11.4 vs. 6.8 months, p = 0.03), but not in patients previously treated with WBRT and salvaged with SRS (n = 39, 6.5 vs. 5.6 months, p = 0.76). Additional lesion detection attributed to 3D-TSE imaging was greater in WBRT-naïve (19.6 %) than in post-WBRT patients (12.0 %) (p < 0.001). The dual-sequence imaging may improve time to distant failure in the modern era for most patients treated with primary stereotactic radiosurgery and should be integrated into the SRS workflow.

U2 - 10.1016/j.radonc.2025.111172

DO - 10.1016/j.radonc.2025.111172

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