Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism

Richard J. O'Reilly; Guenther Koehne; Glenn Heller; Farid Boulad; Hugo Castro-Malaspina; Sergio A. Giralt; Ann A. Jakubowski; Nancy A. Kernan; Esperanza B. Papadopoulos; Miguel Perales; Susan E. Prockop; Marcel R.M. van den Brink; James W. Young; Susan Hsu

doi:10.1016/J.BBMT.2019.12.408

Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism

Richard J. O'Reilly
, Guenther Koehne
, Glenn Heller
, Farid Boulad
, Hugo Castro-Malaspina
, Sergio A. Giralt
, Ann A. Jakubowski
, Nancy A. Kernan
, Esperanza B. Papadopoulos
, Miguel Perales
, Susan E. Prockop
, Marcel R.M. van den Brink
, James W. Young
, Susan Hsu

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biology of Blood and Marrow Transplantation
Volume	26
DOIs	https://doi.org/10.1016/J.BBMT.2019.12.408
State	Published - Mar 1 2020

Disciplines

Medicine and Health Sciences
Oncology
Internal Medicine
Immunology and Infectious Disease

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O'Reilly, R. J., Koehne, G., Heller, G., Boulad, F., Castro-Malaspina, H., Giralt, S. A., Jakubowski, A. A., Kernan, N. A., Papadopoulos, E. B., Perales, M., Prockop, S. E., van den Brink, M. R. M., Young, J. W., & Hsu, S. (2020). Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism. Biology of Blood and Marrow Transplantation, 26. https://doi.org/10.1016/J.BBMT.2019.12.408

Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism. / O'Reilly, Richard J.; Koehne, Guenther; Heller, Glenn et al.
In: Biology of Blood and Marrow Transplantation, Vol. 26, 01.03.2020.

Research output: Contribution to journal › Article › peer-review

O'Reilly, RJ, Koehne, G, Heller, G, Boulad, F, Castro-Malaspina, H, Giralt, SA, Jakubowski, AA, Kernan, NA, Papadopoulos, EB, Perales, M, Prockop, SE, van den Brink, MRM, Young, JW & Hsu, S 2020, 'Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism', Biology of Blood and Marrow Transplantation, vol. 26. https://doi.org/10.1016/J.BBMT.2019.12.408

O'Reilly RJ, Koehne G, Heller G, Boulad F, Castro-Malaspina H, Giralt SA et al. Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism. Biology of Blood and Marrow Transplantation. 2020 Mar 1;26. doi: 10.1016/J.BBMT.2019.12.408

@article{93118766f8e64906954d0d8c6faf72b8,

title = "Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism",

author = "O'Reilly, \{Richard J.\} and Guenther Koehne and Glenn Heller and Farid Boulad and Hugo Castro-Malaspina and Giralt, \{Sergio A.\} and Jakubowski, \{Ann A.\} and Kernan, \{Nancy A.\} and Papadopoulos, \{Esperanza B.\} and Miguel Perales and Prockop, \{Susan E.\} and \{van den Brink\}, \{Marcel R.M.\} and Young, \{James W.\} and Susan Hsu",

note = "Isolated mixed T-cell chimerism in otherwise fully engrafted recipients of TCDHCT has been associated, in some series, with risk of graft rejection or relapses and an indication for DLI. Thereto, we have analyzed the impact of donor chimerism on outcomes in a prospective clinical trial of conditioning regimens used with CD34+ selected TCDHCT.",

year = "2020",

month = mar,

day = "1",

doi = "10.1016/J.BBMT.2019.12.408",

language = "American English",

volume = "26",

journal = "Biology of Blood and Marrow Transplantation",

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TY - JOUR

T1 - Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism

AU - O'Reilly, Richard J.

AU - Koehne, Guenther

AU - Heller, Glenn

AU - Boulad, Farid

AU - Castro-Malaspina, Hugo

AU - Giralt, Sergio A.

AU - Jakubowski, Ann A.

AU - Kernan, Nancy A.

AU - Papadopoulos, Esperanza B.

AU - Perales, Miguel

AU - Prockop, Susan E.

AU - van den Brink, Marcel R.M.

AU - Young, James W.

AU - Hsu, Susan

N1 - Isolated mixed T-cell chimerism in otherwise fully engrafted recipients of TCDHCT has been associated, in some series, with risk of graft rejection or relapses and an indication for DLI. Thereto, we have analyzed the impact of donor chimerism on outcomes in a prospective clinical trial of conditioning regimens used with CD34+ selected TCDHCT.

PY - 2020/3/1

Y1 - 2020/3/1

UR - https://www.sciencedirect.com/science/article/pii/S1083879119313370

U2 - 10.1016/J.BBMT.2019.12.408

DO - 10.1016/J.BBMT.2019.12.408

M3 - Article

VL - 26

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

ER -

Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism

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