First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors

Mark Yarchoan; John D. Powderly; Bruno R. Bastos; Thomas B. Karasic; Oxana V. Crysler; Pamela N. Munster; Meredith A. McKean; Leisha A. Emens; Yvonne M. Saenger; Yasser Ged; Robert Stagg; Steven Smith; Chan C. Whiting; Anne Moon; Peppi Prasit; Yonchu Jenkins; Nathan Standifer; Thomas W. Dubensky; Sam H. Whiting; Susanna V. Ulahannan

doi:10.1158/2767-9764.CRC-24-0082

First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors

Mark Yarchoan, John D. Powderly, Bruno R. Bastos, Thomas B. Karasic, Oxana V. Crysler, Pamela N. Munster, Meredith A. McKean, Leisha A. Emens, Yvonne M. Saenger, Yasser Ged, Robert Stagg, Steven Smith, Chan C. Whiting, Anne Moon, Peppi Prasit, Yonchu Jenkins, Nathan Standifer, Thomas W. Dubensky, Sam H. Whiting, Susanna V. Ulahannan

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1100-1110
Number of pages	11
Journal	Cancer Research Communications
Volume	4
Issue number	4
DOIs	https://doi.org/10.1158/2767-9764.CRC-24-0082
State	Published - Apr 2024
Externally published	Yes

ASJC Scopus Subject Areas

Oncology
Cancer Research
General Medicine

Access to Document

10.1158/2767-9764.CRC-24-0082

Cite this

Yarchoan, M., Powderly, J. D., Bastos, B. R., Karasic, T. B., Crysler, O. V., Munster, P. N., McKean, M. A., Emens, L. A., Saenger, Y. M., Ged, Y., Stagg, R., Smith, S., Whiting, C. C., Moon, A., Prasit, P., Jenkins, Y., Standifer, N., Dubensky, T. W., Whiting, S. H., & Ulahannan, S. V. (2024). First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors. Cancer Research Communications, 4(4), 1100-1110. https://doi.org/10.1158/2767-9764.CRC-24-0082

Yarchoan, M, Powderly, JD, Bastos, BR, Karasic, TB, Crysler, OV, Munster, PN, McKean, MA, Emens, LA, Saenger, YM, Ged, Y, Stagg, R, Smith, S, Whiting, CC, Moon, A, Prasit, P, Jenkins, Y, Standifer, N, Dubensky, TW, Whiting, SH & Ulahannan, SV 2024, 'First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors', Cancer Research Communications, vol. 4, no. 4, pp. 1100-1110. https://doi.org/10.1158/2767-9764.CRC-24-0082

@article{3319be8971b84d33999b844f0ebe7de8,

title = "First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors",

author = "Mark Yarchoan and Powderly, {John D.} and Bastos, {Bruno R.} and Karasic, {Thomas B.} and Crysler, {Oxana V.} and Munster, {Pamela N.} and McKean, {Meredith A.} and Emens, {Leisha A.} and Saenger, {Yvonne M.} and Yasser Ged and Robert Stagg and Steven Smith and Whiting, {Chan C.} and Anne Moon and Peppi Prasit and Yonchu Jenkins and Nathan Standifer and Dubensky, {Thomas W.} and Whiting, {Sam H.} and Ulahannan, {Susanna V.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors; Published by the American Association for Cancer Research.",

year = "2024",

month = apr,

doi = "10.1158/2767-9764.CRC-24-0082",

language = "English",

volume = "4",

pages = "1100--1110",

journal = "Cancer Research Communications",

issn = "2767-9764",

number = "4",

}

TY - JOUR

T1 - First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors

AU - Yarchoan, Mark

AU - Powderly, John D.

AU - Bastos, Bruno R.

AU - Karasic, Thomas B.

AU - Crysler, Oxana V.

AU - Munster, Pamela N.

AU - McKean, Meredith A.

AU - Emens, Leisha A.

AU - Saenger, Yvonne M.

AU - Ged, Yasser

AU - Stagg, Robert

AU - Smith, Steven

AU - Whiting, Chan C.

AU - Moon, Anne

AU - Prasit, Peppi

AU - Jenkins, Yonchu

AU - Standifer, Nathan

AU - Dubensky, Thomas W.

AU - Whiting, Sam H.

AU - Ulahannan, Susanna V.

PY - 2024/4

Y1 - 2024/4

UR - http://www.scopus.com/inward/record.url?scp=85190839248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85190839248&partnerID=8YFLogxK

U2 - 10.1158/2767-9764.CRC-24-0082

DO - 10.1158/2767-9764.CRC-24-0082

M3 - Article

C2 - 38551394

AN - SCOPUS:85190839248

SN - 2767-9764

VL - 4

SP - 1100

EP - 1110

JO - Cancer Research Communications

JF - Cancer Research Communications

IS - 4

ER -

First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this