Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

Kun Xu; Xizeng Mao; Minesh Mehta; Juan Cui; Chi Zhang; Fenglou Mao; Ying Xu

doi:10.1371/journal.pone.0071177

Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

Kun Xu, Xizeng Mao, Minesh Mehta, Juan Cui, Chi Zhang, Fenglou Mao, Ying Xu

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Plos One
Volume	8
DOIs	https://doi.org/10.1371/journal.pone.0071177
State	Published - Aug 14 2013

Disciplines

Biology
Biochemistry
Cell Biology

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10.1371/journal.pone.0071177License: Unspecified

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@article{a6184ae7cfa24c52981959b1e3b23326,

title = "Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis",

author = "Kun Xu and Xizeng Mao and Minesh Mehta and Juan Cui and Chi Zhang and Fenglou Mao and Ying Xu",

note = "The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in cancer cells, which tri mechanisms to transport them out, hence leading to increased acidity in their extracellular environments. It has been well established that the increased acidity will induce cell death of normal cells but not cancer cells.",

year = "2013",

month = aug,

day = "14",

doi = "10.1371/journal.pone.0071177",

language = "American English",

volume = "8",

journal = "Plos One",

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TY - JOUR

T1 - Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

AU - Xu, Kun

AU - Mao, Xizeng

AU - Mehta, Minesh

AU - Cui, Juan

AU - Zhang, Chi

AU - Mao, Fenglou

AU - Xu, Ying

N1 - The rapid growth of cancer cells fueled by glycolysis produces large amounts of protons in cancer cells, which tri mechanisms to transport them out, hence leading to increased acidity in their extracellular environments. It has been well established that the increased acidity will induce cell death of normal cells but not cancer cells.

PY - 2013/8/14

Y1 - 2013/8/14

UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071177

U2 - 10.1371/journal.pone.0071177

DO - 10.1371/journal.pone.0071177

M3 - Article

VL - 8

JO - Plos One

JF - Plos One

ER -

Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

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