Effect of Diazoxide and Hydralazine on Intestinal Transit and Blood Pressure in the Rat

Fernando A Moya; Z. Pober; T.J. Maher

doi:10.1111/j.1600-0773.1989.tb00600.x

Effect of Diazoxide and Hydralazine on Intestinal Transit and Blood Pressure in the Rat

Fernando A Moya
, Z. Pober
, T.J. Maher

Baptist Health Orthopedic Institute

Research output: Contribution to journal › Article › peer-review

Abstract

This study examines the effects of diazoxide and hydralazine on gastrointestinal and vascular smooth muscle. The effect of the drugs administered individually and in combination was determined on small intestinal transit and blood pressure in adult male Sprague-Dawley rats. Both diazoxide and hydralazine produced dose-dependent decreases in the ratio of intestinal transit to total length. Additionally, combinations of various doses of hydralazine and diazoxide produced a greater than simple summation of the inhibitory effects on intestinal transit. The combination of diazoxide and hydralazine produced only a simple additive effect on mean arterial pressure.

Original language	American English
Journal	Pharmacology & Toxicology
Volume	64
DOIs	https://doi.org/10.1111/j.1600-0773.1989.tb00600.x
State	Published - 1989

Disciplines

Medicine and Health Sciences

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title = "Effect of Diazoxide and Hydralazine on Intestinal Transit and Blood Pressure in the Rat",

abstract = " This study examines the effects of diazoxide and hydralazine on gastrointestinal and vascular smooth muscle. The effect of the drugs administered individually and in combination was determined on small intestinal transit and blood pressure in adult male Sprague-Dawley rats. Both diazoxide and hydralazine produced dose-dependent decreases in the ratio of intestinal transit to total length. Additionally, combinations of various doses of hydralazine and diazoxide produced a greater than simple summation of the inhibitory effects on intestinal transit. The combination of diazoxide and hydralazine produced only a simple additive effect on mean arterial pressure. ",

author = "Moya, \{Fernando A\} and Z. Pober and T.J. Maher",

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language = "American English",

volume = "64",

journal = "Pharmacology \& Toxicology",

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T1 - Effect of Diazoxide and Hydralazine on Intestinal Transit and Blood Pressure in the Rat

AU - Moya, Fernando A

AU - Pober, Z.

AU - Maher, T.J.

N1 - This study examines the effects of diazoxide and hydralazine on gastrointestinal and vascular smooth muscle. The effect of the drugs administered individually and in combination was determined on small intestinal transit and blood pressure in adult male Sprague-Dawley rats. Both diazoxide and hydral ...

PY - 1989

Y1 - 1989

N2 - This study examines the effects of diazoxide and hydralazine on gastrointestinal and vascular smooth muscle. The effect of the drugs administered individually and in combination was determined on small intestinal transit and blood pressure in adult male Sprague-Dawley rats. Both diazoxide and hydralazine produced dose-dependent decreases in the ratio of intestinal transit to total length. Additionally, combinations of various doses of hydralazine and diazoxide produced a greater than simple summation of the inhibitory effects on intestinal transit. The combination of diazoxide and hydralazine produced only a simple additive effect on mean arterial pressure.

AB - This study examines the effects of diazoxide and hydralazine on gastrointestinal and vascular smooth muscle. The effect of the drugs administered individually and in combination was determined on small intestinal transit and blood pressure in adult male Sprague-Dawley rats. Both diazoxide and hydralazine produced dose-dependent decreases in the ratio of intestinal transit to total length. Additionally, combinations of various doses of hydralazine and diazoxide produced a greater than simple summation of the inhibitory effects on intestinal transit. The combination of diazoxide and hydralazine produced only a simple additive effect on mean arterial pressure.

UR - https://pubmed.ncbi.nlm.nih.gov/2755911/

U2 - 10.1111/j.1600-0773.1989.tb00600.x

DO - 10.1111/j.1600-0773.1989.tb00600.x

M3 - Article

VL - 64

JO - Pharmacology & Toxicology

JF - Pharmacology & Toxicology

ER -

Effect of Diazoxide and Hydralazine on Intestinal Transit and Blood Pressure in the Rat

Abstract

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