Association of cystic fibrosis with abnormalities in fatty acid metabolism

Steven D. Freedman; Paola G. Blanco; Munir M. Zaman; Julie C. Shea; Mario Ollero; Isabel K. Hopper; Deborah A. Weed; Andres Gelrud; Meredith M. Regan; Michael Laposata; Juan G. Alvarez; Brian P. O'Sullivan

doi:10.1056/NEJMoa021218

Association of cystic fibrosis with abnormalities in fatty acid metabolism

Steven D. Freedman, Paola G. Blanco, Munir M. Zaman, Julie C. Shea, Mario Ollero, Isabel K. Hopper, Deborah A. Weed, Andres Gelrud, Meredith M. Regan, Michael Laposata, Juan G. Alvarez, Brian P. O'Sullivan

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	The New England Journal of Medicine
Volume	350
DOIs	https://doi.org/10.1056/NEJMoa021218
State	Published - Feb 5 2004
Externally published	Yes

Disciplines

Internal Medicine
Medicine and Health Sciences
Endocrinology

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10.1056/NEJMoa021218License: Unspecified

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@article{7b6e481bdf554ebd820b156861f5753f,

title = "Association of cystic fibrosis with abnormalities in fatty acid metabolism",

author = "Freedman, \{Steven D.\} and Blanco, \{Paola G.\} and Zaman, \{Munir M.\} and Shea, \{Julie C.\} and Mario Ollero and Hopper, \{Isabel K.\} and Weed, \{Deborah A.\} and Andres Gelrud and Regan, \{Meredith M.\} and Michael Laposata and Alvarez, \{Juan G.\} and O'Sullivan, \{Brian P.\}",

note = "BACKGROUND: Patients with cystic fibrosis have altered levels of plasma fatty acids. We previously demonstrated that arachidonic acid levels are increased and docosahexaenoic acid levels are decreased in affected tissues from cystic fibrosis-knockout mice. In this study we determined whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid defect in tissues expressing CFTR.",

year = "2004",

month = feb,

day = "5",

doi = "10.1056/NEJMoa021218",

language = "American English",

volume = "350",

journal = "The New England Journal of Medicine",

}

TY - JOUR

T1 - Association of cystic fibrosis with abnormalities in fatty acid metabolism

AU - Freedman, Steven D.

AU - Blanco, Paola G.

AU - Zaman, Munir M.

AU - Shea, Julie C.

AU - Ollero, Mario

AU - Hopper, Isabel K.

AU - Weed, Deborah A.

AU - Gelrud, Andres

AU - Regan, Meredith M.

AU - Laposata, Michael

AU - Alvarez, Juan G.

AU - O'Sullivan, Brian P.

N1 - BACKGROUND: Patients with cystic fibrosis have altered levels of plasma fatty acids. We previously demonstrated that arachidonic acid levels are increased and docosahexaenoic acid levels are decreased in affected tissues from cystic fibrosis-knockout mice. In this study we determined whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid defect in tissues expressing CFTR.

PY - 2004/2/5

Y1 - 2004/2/5

UR - https://escholarship.umassmed.edu/peds_pulmonary/7/

U2 - 10.1056/NEJMoa021218

DO - 10.1056/NEJMoa021218

M3 - Article

VL - 350

JO - The New England Journal of Medicine

JF - The New England Journal of Medicine

ER -

Association of cystic fibrosis with abnormalities in fatty acid metabolism

Disciplines

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