Aortic valve bypass for aortic stenosis in a patient with paroxysmal nocturnal hemoglobinuria

Mehrdad Ghoreishi; Maria R Baer; Ranjana Bhargava; Craig E Stauffer; Bartley P Griffith; James S Gammie

doi:10.1016/j.athoracsur.2009.11.047

Aortic valve bypass for aortic stenosis in a patient with paroxysmal nocturnal hemoglobinuria

Mehrdad Ghoreishi, Maria R Baer, Ranjana Bhargava, Craig E Stauffer, Bartley P Griffith, James S Gammie

Research output: Contribution to journal › Article › peer-review

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.

Original language	English
Pages (from-to)	279-81
Number of pages	3
Journal	The Annals of thoracic surgery
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/j.athoracsur.2009.11.047
State	Published - Jun 2010
Externally published	Yes

Keywords

Aged
Aortic Valve Stenosis/complications
Cardiac Surgical Procedures/methods
Hemoglobinuria, Paroxysmal/complications
Humans
Male

Access to Document

10.1016/j.athoracsur.2009.11.047

Cite this

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title = "Aortic valve bypass for aortic stenosis in a patient with paroxysmal nocturnal hemoglobinuria",

abstract = "Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.",

keywords = "Aged, Aortic Valve Stenosis/complications, Cardiac Surgical Procedures/methods, Hemoglobinuria, Paroxysmal/complications, Humans, Male",

author = "Mehrdad Ghoreishi and Baer, \{Maria R\} and Ranjana Bhargava and Stauffer, \{Craig E\} and Griffith, \{Bartley P\} and Gammie, \{James S\}",

year = "2010",

month = jun,

doi = "10.1016/j.athoracsur.2009.11.047",

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AU - Ghoreishi, Mehrdad

AU - Baer, Maria R

AU - Bhargava, Ranjana

AU - Stauffer, Craig E

AU - Griffith, Bartley P

AU - Gammie, James S

PY - 2010/6

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N2 - Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.

AB - Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.

KW - Aged

KW - Aortic Valve Stenosis/complications

KW - Cardiac Surgical Procedures/methods

KW - Hemoglobinuria, Paroxysmal/complications

KW - Humans

KW - Male

U2 - 10.1016/j.athoracsur.2009.11.047

DO - 10.1016/j.athoracsur.2009.11.047

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SN - 0003-4975

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IS - 1

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