Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial

Michael Lim; Xiaobu Ye; Anna F. Piotrowski; Arati Desai; Manmeet S. Ahluwalia; Tobias Walbert; Glenn Lesser; Benjamin M. Ellingson; David M. Peereboom; Joy D. Fisher; Serena Desideri; Christina Jackson; Ayush Pant; Aanchal Jain; Rohit Verma; Benjamin Oberlton; Hadeesha Piyadasa; Chetan Bettegowda; Logan Engle; Janis Taube; Sean C. Bendall; John Choi; Jan Drappatz; Frank S. Lieberman; Lawrence R. Kleinberg; Drew M. Pardoll; Louis B. Nabors; Patrick Y. Wen; Stuart A. Grossman

doi:10.1038/s41591-026-04475-7

Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial

Michael Lim
, Xiaobu Ye
, Anna F. Piotrowski
, Arati Desai
, Manmeet S. Ahluwalia
, Tobias Walbert
, Glenn Lesser
, Benjamin M. Ellingson
, David M. Peereboom
, Joy D. Fisher
, Serena Desideri
, Christina Jackson
, Ayush Pant
, Aanchal Jain
, Rohit Verma
, Benjamin Oberlton
, Hadeesha Piyadasa
, Chetan Bettegowda
, Logan Engle
, Janis Taube

Sean C. Bendall, John Choi, Jan Drappatz, Frank S. Lieberman, Lawrence R. Kleinberg, Drew M. Pardoll, Louis B. Nabors, Patrick Y. Wen, Stuart A. Grossman

Baptist Health South Florida

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2449-2460
Number of pages	12
Journal	Nature medicine
Volume	32
Issue number	7
DOIs	https://doi.org/10.1038/s41591-026-04475-7
State	Published - Jul 2026

ASJC Scopus Subject Areas

General Medicine
General Biochemistry,Genetics and Molecular Biology

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10.1038/s41591-026-04475-7

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Lim, M., Ye, X., Piotrowski, A. F., Desai, A., Ahluwalia, M. S., Walbert, T., Lesser, G., Ellingson, B. M., Peereboom, D. M., Fisher, J. D., Desideri, S., Jackson, C., Pant, A., Jain, A., Verma, R., Oberlton, B., Piyadasa, H., Bettegowda, C., Engle, L., ... Grossman, S. A. (2026). Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial. Nature medicine, 32(7), 2449-2460. https://doi.org/10.1038/s41591-026-04475-7

Lim, M, Ye, X, Piotrowski, AF, Desai, A, Ahluwalia, MS, Walbert, T, Lesser, G, Ellingson, BM, Peereboom, DM, Fisher, JD, Desideri, S, Jackson, C, Pant, A, Jain, A, Verma, R, Oberlton, B, Piyadasa, H, Bettegowda, C, Engle, L, Taube, J, Bendall, SC, Choi, J, Drappatz, J, Lieberman, FS, Kleinberg, LR, Pardoll, DM, Nabors, LB, Wen, PY & Grossman, SA 2026, 'Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial', Nature medicine, vol. 32, no. 7, pp. 2449-2460. https://doi.org/10.1038/s41591-026-04475-7

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title = "Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial",

author = "Michael Lim and Xiaobu Ye and Piotrowski, \{Anna F.\} and Arati Desai and Ahluwalia, \{Manmeet S.\} and Tobias Walbert and Glenn Lesser and Ellingson, \{Benjamin M.\} and Peereboom, \{David M.\} and Fisher, \{Joy D.\} and Serena Desideri and Christina Jackson and Ayush Pant and Aanchal Jain and Rohit Verma and Benjamin Oberlton and Hadeesha Piyadasa and Chetan Bettegowda and Logan Engle and Janis Taube and Bendall, \{Sean C.\} and John Choi and Jan Drappatz and Lieberman, \{Frank S.\} and Kleinberg, \{Lawrence R.\} and Pardoll, \{Drew M.\} and Nabors, \{Louis B.\} and Wen, \{Patrick Y.\} and Grossman, \{Stuart A.\}",

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doi = "10.1038/s41591-026-04475-7",

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AU - Piotrowski, Anna F.

AU - Desai, Arati

AU - Ahluwalia, Manmeet S.

AU - Walbert, Tobias

AU - Lesser, Glenn

AU - Ellingson, Benjamin M.

AU - Peereboom, David M.

AU - Fisher, Joy D.

AU - Desideri, Serena

AU - Jackson, Christina

AU - Pant, Ayush

AU - Jain, Aanchal

AU - Verma, Rohit

AU - Oberlton, Benjamin

AU - Piyadasa, Hadeesha

AU - Bettegowda, Chetan

AU - Engle, Logan

AU - Taube, Janis

AU - Bendall, Sean C.

AU - Choi, John

AU - Drappatz, Jan

AU - Lieberman, Frank S.

AU - Kleinberg, Lawrence R.

AU - Pardoll, Drew M.

AU - Nabors, Louis B.

AU - Wen, Patrick Y.

AU - Grossman, Stuart A.

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Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial

ASJC Scopus Subject Areas

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