An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Deliang Guo; Felicia Reinitz; Mary Youssef; Cynthia Hong; David Nathanson; David Akhavan; Daisuke Kuga; Ali Nael Amzajerdi; Horacio Soto; Shaojun Zhu; Ivan Babic; Kazuhiro Tanaka; Julie Dang; Akio Iwanami; Beatrice Gini; Jason DeJesus; Dominique D. Lisiero; Tiffany T. Huang; Robert M. Prins; Patrick Y. Wen; H. Ian Robins; Michael D. Prados; Lisa M. DeAngelis; Ingo K. Mellinghoff; Minesh P. Mehta; C. David James; Arnab Chakravarti; Timothy F. Cloughesy; Peter Tontonoz; Paul S. Mischel

doi:10.1158/2159-8290.CD-11-0102

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Deliang Guo
, Felicia Reinitz
, Mary Youssef
, Cynthia Hong
, David Nathanson
, David Akhavan
, Daisuke Kuga
, Ali Nael Amzajerdi
, Horacio Soto
, Shaojun Zhu
, Ivan Babic
, Kazuhiro Tanaka
, Julie Dang
, Akio Iwanami
, Beatrice Gini
, Jason DeJesus
, Dominique D. Lisiero
, Tiffany T. Huang
, Robert M. Prins
, Patrick Y. Wen

H. Ian Robins, Michael D. Prados, Lisa M. DeAngelis, Ingo K. Mellinghoff, Minesh P. Mehta, C. David James, Arnab Chakravarti, Timothy F. Cloughesy, Peter Tontonoz, Paul S. Mischel

Miami Cancer Institute

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Cancer Discovery
Volume	1
DOIs	https://doi.org/10.1158/2159-8290.CD-11-0102
State	Published - Oct 1 2011

Disciplines

Biology
Immunology and Infectious Disease

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Guo, D., Reinitz, F., Youssef, M., Hong, C., Nathanson, D., Akhavan, D., Kuga, D., Amzajerdi, A. N., Soto, H., Zhu, S., Babic, I., Tanaka, K., Dang, J., Iwanami, A., Gini, B., DeJesus, J., Lisiero, D. D., Huang, T. T., Prins, R. M., ... Mischel, P. S. (2011). An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway. Cancer Discovery, 1. https://doi.org/10.1158/2159-8290.CD-11-0102

Guo, D, Reinitz, F, Youssef, M, Hong, C, Nathanson, D, Akhavan, D, Kuga, D, Amzajerdi, AN, Soto, H, Zhu, S, Babic, I, Tanaka, K, Dang, J, Iwanami, A, Gini, B, DeJesus, J, Lisiero, DD, Huang, TT, Prins, RM, Wen, PY, Robins, HI, Prados, MD, DeAngelis, LM, Mellinghoff, IK, Mehta, MP, James, CD, Chakravarti, A, Cloughesy, TF, Tontonoz, P & Mischel, PS 2011, 'An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway', Cancer Discovery, vol. 1. https://doi.org/10.1158/2159-8290.CD-11-0102

@article{a5c2be708b6d47c18a38e47018af4361,

title = "An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway",

author = "Deliang Guo and Felicia Reinitz and Mary Youssef and Cynthia Hong and David Nathanson and David Akhavan and Daisuke Kuga and Amzajerdi, \{Ali Nael\} and Horacio Soto and Shaojun Zhu and Ivan Babic and Kazuhiro Tanaka and Julie Dang and Akio Iwanami and Beatrice Gini and Jason DeJesus and Lisiero, \{Dominique D.\} and Huang, \{Tiffany T.\} and Prins, \{Robert M.\} and Wen, \{Patrick Y.\} and Robins, \{H. Ian\} and Prados, \{Michael D.\} and DeAngelis, \{Lisa M.\} and Mellinghoff, \{Ingo K.\} and Mehta, \{Minesh P.\} and James, \{C. David\} and Arnab Chakravarti and Cloughesy, \{Timothy F.\} and Peter Tontonoz and Mischel, \{Paul S.\}",

note = "Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of the most lethal of all cancers. Epidermal growth factor receptor (EGFR) mutations (EGFRvIII) and phosphoinositide 3-kinase (PI3K) hyperactivation are common in GBM, promoting tumor growth and survival, including through sterol regulatory element-binding protein 1 (SREBP-1)-dependent lipogenesis.",

year = "2011",

month = oct,

day = "1",

doi = "10.1158/2159-8290.CD-11-0102",

language = "American English",

volume = "1",

journal = "Cancer Discovery",

}

TY - JOUR

T1 - An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

AU - Guo, Deliang

AU - Reinitz, Felicia

AU - Youssef, Mary

AU - Hong, Cynthia

AU - Nathanson, David

AU - Akhavan, David

AU - Kuga, Daisuke

AU - Amzajerdi, Ali Nael

AU - Soto, Horacio

AU - Zhu, Shaojun

AU - Babic, Ivan

AU - Tanaka, Kazuhiro

AU - Dang, Julie

AU - Iwanami, Akio

AU - Gini, Beatrice

AU - DeJesus, Jason

AU - Lisiero, Dominique D.

AU - Huang, Tiffany T.

AU - Prins, Robert M.

AU - Wen, Patrick Y.

AU - Robins, H. Ian

AU - Prados, Michael D.

AU - DeAngelis, Lisa M.

AU - Mellinghoff, Ingo K.

AU - Mehta, Minesh P.

AU - James, C. David

AU - Chakravarti, Arnab

AU - Cloughesy, Timothy F.

AU - Tontonoz, Peter

AU - Mischel, Paul S.

N1 - Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of the most lethal of all cancers. Epidermal growth factor receptor (EGFR) mutations (EGFRvIII) and phosphoinositide 3-kinase (PI3K) hyperactivation are common in GBM, promoting tumor growth and survival, including through sterol regulatory element-binding protein 1 (SREBP-1)-dependent lipogenesis.

PY - 2011/10/1

Y1 - 2011/10/1

UR - http://cancerdiscovery.aacrjournals.org/content/1/5/442

U2 - 10.1158/2159-8290.CD-11-0102

DO - 10.1158/2159-8290.CD-11-0102

M3 - Article

VL - 1

JO - Cancer Discovery

JF - Cancer Discovery

ER -

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

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