Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants

Guenther Koehne; Aisha N. Hasan; Ekaterina Doubrovina; Eleanor Tyler; Susan E. Prockop; Juliet N Barker; Hugo R Castro-Malaspina; Miguel-Angel Perales; Craig S. Sauter; Ann A. Jakubowski; Esperanza B. Papadopoulos; James W. Young; Farid Boulad; Trudy N. Small; Nancy A. Kernan; Gloria Wasilewski; Andromachi Scaradavou; Sergio A. Giralt; Marcel R.M. van den Brink; Richard J. O'Reilly

Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants

Guenther Koehne, Aisha N. Hasan, Ekaterina Doubrovina, Eleanor Tyler, Susan E. Prockop, Juliet N Barker, Hugo R Castro-Malaspina, Miguel-Angel Perales, Craig S. Sauter, Ann A. Jakubowski, Esperanza B. Papadopoulos, James W. Young, Farid Boulad, Trudy N. Small, Nancy A. Kernan, Gloria Wasilewski, Andromachi Scaradavou, Sergio A. Giralt, Marcel R.M. van den Brink, Richard J. O'Reilly

Miami Cancer Institute

Research output: Contribution to conference › Presentation

Original language	American English
State	Published - Nov 16 2012
Event	Blood - Duration: Jan 1 2020 → …

Conference

Conference	Blood
Period	1/1/20 → …

Disciplines

Virology
Medicine and Health Sciences
Immunology and Infectious Disease

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Koehne, G., Hasan, A. N., Doubrovina, E., Tyler, E., Prockop, S. E., Barker, J. N., Castro-Malaspina, H. R., Perales, M.-A., Sauter, C. S., Jakubowski, A. A., Papadopoulos, E. B., Young, J. W., Boulad, F., Small, T. N., Kernan, N. A., Wasilewski, G., Scaradavou, A., Giralt, S. A., van den Brink, M. R. M., & O'Reilly, R. J. (2012). Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants. Blood.

Koehne, G, Hasan, AN, Doubrovina, E, Tyler, E, Prockop, SE, Barker, JN, Castro-Malaspina, HR, Perales, M-A, Sauter, CS, Jakubowski, AA, Papadopoulos, EB, Young, JW, Boulad, F, Small, TN, Kernan, NA, Wasilewski, G, Scaradavou, A, Giralt, SA, van den Brink, MRM & O'Reilly, RJ 2012, 'Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants', Blood, 1/1/20.

@conference{fdb31e5f2c8e46e8ad6d68be64d85f6c,

title = "Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants",

author = "Guenther Koehne and Hasan, \{Aisha N.\} and Ekaterina Doubrovina and Eleanor Tyler and Prockop, \{Susan E.\} and Barker, \{Juliet N\} and Castro-Malaspina, \{Hugo R\} and Miguel-Angel Perales and Sauter, \{Craig S.\} and Jakubowski, \{Ann A.\} and Papadopoulos, \{Esperanza B.\} and Young, \{James W.\} and Farid Boulad and Small, \{Trudy N.\} and Kernan, \{Nancy A.\} and Gloria Wasilewski and Andromachi Scaradavou and Giralt, \{Sergio A.\} and \{van den Brink\}, \{Marcel R.M.\} and O'Reilly, \{Richard J.\}",

note = "Abstract 351 We have generated donor-derived T-cell lines specific for CMVpp65 peptides for use in a phase I, dose escalation trial of adoptive immunotherapy. T-cells were sensitized by autologous monocyte-derived DCs loaded with a pool of 138 pentadecapeptides (15-mers), with 11 amino acid overlaps spanning the entire 561 amino acid sequence of the CMV protein pp65.; Blood ; Conference date: 01-01-2020",

year = "2012",

month = nov,

day = "16",

language = "American English",

}

TY - CONF

T1 - Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants

AU - Koehne, Guenther

AU - Hasan, Aisha N.

AU - Doubrovina, Ekaterina

AU - Tyler, Eleanor

AU - Prockop, Susan E.

AU - Barker, Juliet N

AU - Castro-Malaspina, Hugo R

AU - Perales, Miguel-Angel

AU - Sauter, Craig S.

AU - Jakubowski, Ann A.

AU - Papadopoulos, Esperanza B.

AU - Young, James W.

AU - Boulad, Farid

AU - Small, Trudy N.

AU - Kernan, Nancy A.

AU - Wasilewski, Gloria

AU - Scaradavou, Andromachi

AU - Giralt, Sergio A.

AU - van den Brink, Marcel R.M.

AU - O'Reilly, Richard J.

N1 - Abstract 351 We have generated donor-derived T-cell lines specific for CMVpp65 peptides for use in a phase I, dose escalation trial of adoptive immunotherapy. T-cells were sensitized by autologous monocyte-derived DCs loaded with a pool of 138 pentadecapeptides (15-mers), with 11 amino acid overlaps spanning the entire 561 amino acid sequence of the CMV protein pp65.

PY - 2012/11/16

Y1 - 2012/11/16

UR - http://www.bloodjournal.org/content/120/21/351?sso-checked=true

M3 - Presentation

T2 - Blood

Y2 - 1 January 2020

ER -

Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants

Conference

Disciplines

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