A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

Alexander P. Landry; Justin Z. Wang; Vikas Patil; Andrew Ajisebutu; Chloe Gui; Leeor S. Yefet; Yosef Ellenbogen; Jeff Liu; Yasin Mamatjan; Qingxia Wei; Olivia Singh; Sheila Mansouri; Felix Ehret; David Capper; Aaron Cohen-Gadol; Ghazaleh Tabatabai; Marcos Tatagiba; Felix Behling; Jill Barnholtz-Sloan; Andrew E. Sloan; Lola B. Chambless; Alireza Mansouri; Serge Makarenko; Stephen Yip; Derek S. Tsang; Andrew Gao; Kenneth Aldape; Farshad Nassiri; Gelareh Zadeh; Thomas Santarius; Warren Selman; Marta Couce; Andrew E. Sloan; Priscilla K. Brastianos; Helen A. Shih; W. Linda Bi; Raymond Y. Huang; Patrick Y. Wen; Tobias Walbert; Ian Lee; Michelle Felicella; Chaya Brodie; Tathiane Malta; Ana Valeria C. Castro; Houtan Noushmehr; James Snyder; Francesco Dimeco; Andrea Saladino; Bianca Pollo; Christian Schichor; Jorg Christian Tonn; Timothy J. Kaufmann; Daniel Lachance; Caterina Giannini; Evanthia Galanis; Aditya Raghunathan; C. Oliver Hanemann; Karolyn Au; Roland Goldbrunner; Norbert Galldiks; Marco Timmer; Nils Ole Schimdt; Christel Herold-Mende; Felix Sahm; Christine Jungk; Gerhard Jungwirth; Andreas Von Deimling; Michael D. Jenkinson; Christopher P. Millward; Abdurrahman I. Islim; Katharine Drummond; Andrew Morokoff; Ghazaleh Tabatabai; Felix Behling; Mirjam Renovanz; Marcos Tatagiba; Antonio Santacroce; Christian La Fougere; Jens Schittenhelm; David R. Raleigh; Arie Perry; Nicholas Butowski; Manfred Westphal; Katrin Lamszus; Franz Ricklefs; Christian Mawrin; Craig M. Horbinski; Ho Keung Ng; Matija Snuderl; Sylvia Kurz; Erik P. Sulman; Gabriel Zada; Aaron Cohen-Gadol; Stephen Yip; Serge Makarenko; Viktor Zherebitskiy; Luke Hnenny; Ian F. Dunn; Jennifer Moliterno; Michael W. McDermott; Michael Vogelbaum; Mohsen Javadpour; Daniel Fountain; Tiit Illimar Mathiesen; Kenneth Aldape; Jill Barnholtz-Sloan; Omar Pathmanaban; Paul C. Boutros; Tzannis Alkividias; Konstantinos N. Fountas; Kyle M. Walsh; Susan C. Short; Bruno Carvalho; Sybren L.N. Maas; Eelke M. Bos; Alper Dincer; Sylvia Kurz; Peter Passlack; Maximilian Deng; Felix Ehret; Minesh P. Mehta; Yazmin Odia; Richard Everson; James A. Balogun; Clara Lopez; Evan Calabrese; Philipp Karschnia; Nico Teske; Laura Fariselli; Tobias Greve; Christina Arvaniti; Carolina Benjamin; Michael Ivan; Christina Jackson; Sanjeeva Jeyaretna; Daniele Scartoni; Dante Amelio; Joshua Palmer; Jana Ivanidze; Quinn Ostrom; Duong Trung Kien; Mark Youngblood; Miguel Millareschavez; Malak Althgafi; Sam Emerson; Michael Weller; Emilie Lerhun; Rafael Martínez-Pérez; Robert Smee; Raj Mukherjee; Andres Cervio; Clinton Turner; Will Muirhead; Eric Suero Molina; Vitowanu Julius; Jiawei Chen; Brij Karmur; Maciej Mrugala; Brian Neth

doi:10.1093/neuonc/noaf237

A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

Alexander P. Landry
, Justin Z. Wang
, Vikas Patil
, Andrew Ajisebutu
, Chloe Gui
, Leeor S. Yefet
, Yosef Ellenbogen
, Jeff Liu
, Yasin Mamatjan
, Qingxia Wei
, Olivia Singh
, Sheila Mansouri
, Felix Ehret
, David Capper
, Aaron Cohen-Gadol
, Ghazaleh Tabatabai
, Marcos Tatagiba
, Felix Behling
, Jill Barnholtz-Sloan
, Andrew E. Sloan

Lola B. Chambless, Alireza Mansouri, Serge Makarenko, Stephen Yip, Derek S. Tsang, Andrew Gao, Kenneth Aldape, Farshad Nassiri, Gelareh Zadeh, Thomas Santarius, Warren Selman, Marta Couce, Andrew E. Sloan, Priscilla K. Brastianos, Helen A. Shih, W. Linda Bi, Raymond Y. Huang, Patrick Y. Wen, Tobias Walbert, Ian Lee, Michelle Felicella, Chaya Brodie, Tathiane Malta, Ana Valeria C. Castro, Houtan Noushmehr, James Snyder, Francesco Dimeco, Andrea Saladino, Bianca Pollo, Christian Schichor, Jorg Christian Tonn, Timothy J. Kaufmann, Daniel Lachance, Caterina Giannini, Evanthia Galanis, Aditya Raghunathan, C. Oliver Hanemann, Karolyn Au, Roland Goldbrunner, Norbert Galldiks, Marco Timmer, Nils Ole Schimdt, Christel Herold-Mende, Felix Sahm, Christine Jungk, Gerhard Jungwirth, Andreas Von Deimling, Michael D. Jenkinson, Christopher P. Millward, Abdurrahman I. Islim, Katharine Drummond, Andrew Morokoff, Ghazaleh Tabatabai, Felix Behling, Mirjam Renovanz, Marcos Tatagiba, Antonio Santacroce, Christian La Fougere, Jens Schittenhelm, David R. Raleigh, Arie Perry, Nicholas Butowski, Manfred Westphal, Katrin Lamszus, Franz Ricklefs, Christian Mawrin, Craig M. Horbinski, Ho Keung Ng, Matija Snuderl, Sylvia Kurz, Erik P. Sulman, Gabriel Zada, Aaron Cohen-Gadol, Stephen Yip, Serge Makarenko, Viktor Zherebitskiy, Luke Hnenny, Ian F. Dunn, Jennifer Moliterno, Michael W. McDermott, Michael Vogelbaum, Mohsen Javadpour, Daniel Fountain, Tiit Illimar Mathiesen, Kenneth Aldape, Jill Barnholtz-Sloan, Omar Pathmanaban, Paul C. Boutros, Tzannis Alkividias, Konstantinos N. Fountas, Kyle M. Walsh, Susan C. Short, Bruno Carvalho, Sybren L.N. Maas, Eelke M. Bos, Alper Dincer, Sylvia Kurz, Peter Passlack, Maximilian Deng, Felix Ehret, Minesh P. Mehta, Yazmin Odia, Richard Everson, James A. Balogun, Clara Lopez, Evan Calabrese, Philipp Karschnia, Nico Teske, Laura Fariselli, Tobias Greve, Christina Arvaniti, Carolina Benjamin, Michael Ivan, Christina Jackson, Sanjeeva Jeyaretna, Daniele Scartoni, Dante Amelio, Joshua Palmer, Jana Ivanidze, Quinn Ostrom, Duong Trung Kien, Mark Youngblood, Miguel Millareschavez, Malak Althgafi, Sam Emerson, Michael Weller, Emilie Lerhun, Rafael Martínez-Pérez, Robert Smee, Raj Mukherjee, Andres Cervio, Clinton Turner, Will Muirhead, Eric Suero Molina, Vitowanu Julius, Jiawei Chen, Brij Karmur, Maciej Mrugala, Brian Neth

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	430-439
Number of pages	10
Journal	Neuro-Oncology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1093/neuonc/noaf237
State	Published - Feb 1 2026

ASJC Scopus Subject Areas

Oncology
Clinical Neurology
Cancer Research

Keywords

clinical recommendations
DNA methylation
meningioma
neuro-oncology
outcome biomarker

Access to Document

10.1093/neuonc/noaf237

Cite this

Landry, A. P., Wang, J. Z., Patil, V., Ajisebutu, A., Gui, C., Yefet, L. S., Ellenbogen, Y., Liu, J., Mamatjan, Y., Wei, Q., Singh, O., Mansouri, S., Ehret, F., Capper, D., Cohen-Gadol, A., Tabatabai, G., Tatagiba, M., Behling, F., Barnholtz-Sloan, J., ... Neth, B. (2026). A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma. Neuro-Oncology, 28(2), 430-439. https://doi.org/10.1093/neuonc/noaf237

Landry, AP, Wang, JZ, Patil, V, Ajisebutu, A, Gui, C, Yefet, LS, Ellenbogen, Y, Liu, J, Mamatjan, Y, Wei, Q, Singh, O, Mansouri, S, Ehret, F, Capper, D, Cohen-Gadol, A, Tabatabai, G, Tatagiba, M, Behling, F, Barnholtz-Sloan, J, Sloan, AE, Chambless, LB, Mansouri, A, Makarenko, S, Yip, S, Tsang, DS, Gao, A, Aldape, K, Nassiri, F, Zadeh, G, Santarius, T, Selman, W, Couce, M, Sloan, AE, Brastianos, PK, Shih, HA, Linda Bi, W, Huang, RY, Wen, PY, Walbert, T, Lee, I, Felicella, M, Brodie, C, Malta, T, Castro, AVC, Noushmehr, H, Snyder, J, Dimeco, F, Saladino, A, Pollo, B, Schichor, C, Tonn, JC, Kaufmann, TJ, Lachance, D, Giannini, C, Galanis, E, Raghunathan, A, Hanemann, CO, Au, K, Goldbrunner, R, Galldiks, N, Timmer, M, Ole Schimdt, N, Herold-Mende, C, Sahm, F, Jungk, C, Jungwirth, G, Von Deimling, A, Jenkinson, MD, Millward, CP, Islim, AI, Drummond, K, Morokoff, A, Tabatabai, G, Behling, F, Renovanz, M, Tatagiba, M, Santacroce, A, La Fougere, C, Schittenhelm, J, Raleigh, DR, Perry, A, Butowski, N, Westphal, M, Lamszus, K, Ricklefs, F, Mawrin, C, Horbinski, CM, Ng, HK, Snuderl, M, Kurz, S, Sulman, EP, Zada, G, Cohen-Gadol, A, Yip, S, Makarenko, S, Zherebitskiy, V, Hnenny, L, Dunn, IF, Moliterno, J, McDermott, MW, Vogelbaum, M, Javadpour, M, Fountain, D, Mathiesen, TI, Aldape, K, Barnholtz-Sloan, J, Pathmanaban, O, Boutros, PC, Alkividias, T, Fountas, KN, Walsh, KM, Short, SC, Carvalho, B, Maas, SLN, Bos, EM, Dincer, A, Kurz, S, Passlack, P, Deng, M, Ehret, F, Mehta, MP , Odia, Y, Everson, R, Balogun, JA, Lopez, C, Calabrese, E, Karschnia, P, Teske, N, Fariselli, L, Greve, T, Arvaniti, C, Benjamin, C, Ivan, M, Jackson, C, Jeyaretna, S, Scartoni, D, Amelio, D, Palmer, J, Ivanidze, J, Ostrom, Q, Trung Kien, D, Youngblood, M, Millareschavez, M, Althgafi, M, Emerson, S, Weller, M, Lerhun, E, Martínez-Pérez, R, Smee, R, Mukherjee, R, Cervio, A, Turner, C, Muirhead, W, Molina, ES, Julius, V, Chen, J, Karmur, B, Mrugala, M & Neth, B 2026, 'A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma', Neuro-Oncology, vol. 28, no. 2, pp. 430-439. https://doi.org/10.1093/neuonc/noaf237

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title = "A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma",

keywords = "clinical recommendations, DNA methylation, meningioma, neuro-oncology, outcome biomarker",

author = "Landry, \{Alexander P.\} and Wang, \{Justin Z.\} and Vikas Patil and Andrew Ajisebutu and Chloe Gui and Yefet, \{Leeor S.\} and Yosef Ellenbogen and Jeff Liu and Yasin Mamatjan and Qingxia Wei and Olivia Singh and Sheila Mansouri and Felix Ehret and David Capper and Aaron Cohen-Gadol and Ghazaleh Tabatabai and Marcos Tatagiba and Felix Behling and Jill Barnholtz-Sloan and Sloan, \{Andrew E.\} and Chambless, \{Lola B.\} and Alireza Mansouri and Serge Makarenko and Stephen Yip and Tsang, \{Derek S.\} and Andrew Gao and Kenneth Aldape and Farshad Nassiri and Gelareh Zadeh and Thomas Santarius and Warren Selman and Marta Couce and Sloan, \{Andrew E.\} and Brastianos, \{Priscilla K.\} and Shih, \{Helen A.\} and \{Linda Bi\}, W. and Huang, \{Raymond Y.\} and Wen, \{Patrick Y.\} and Tobias Walbert and Ian Lee and Michelle Felicella and Chaya Brodie and Tathiane Malta and Castro, \{Ana Valeria C.\} and Houtan Noushmehr and James Snyder and Francesco Dimeco and Andrea Saladino and Bianca Pollo and Christian Schichor and Tonn, \{Jorg Christian\} and Kaufmann, \{Timothy J.\} and Daniel Lachance and Caterina Giannini and Evanthia Galanis and Aditya Raghunathan and Hanemann, \{C. Oliver\} and Karolyn Au and Roland Goldbrunner and Norbert Galldiks and Marco Timmer and \{Ole Schimdt\}, Nils and Christel Herold-Mende and Felix Sahm and Christine Jungk and Gerhard Jungwirth and \{Von Deimling\}, Andreas and Jenkinson, \{Michael D.\} and Millward, \{Christopher P.\} and Islim, \{Abdurrahman I.\} and Katharine Drummond and Andrew Morokoff and Ghazaleh Tabatabai and Felix Behling and Mirjam Renovanz and Marcos Tatagiba and Antonio Santacroce and \{La Fougere\}, Christian and Jens Schittenhelm and Raleigh, \{David R.\} and Arie Perry and Nicholas Butowski and Manfred Westphal and Katrin Lamszus and Franz Ricklefs and Christian Mawrin and Horbinski, \{Craig M.\} and Ng, \{Ho Keung\} and Matija Snuderl and Sylvia Kurz and Sulman, \{Erik P.\} and Gabriel Zada and Aaron Cohen-Gadol and Stephen Yip and Serge Makarenko and Viktor Zherebitskiy and Luke Hnenny and Dunn, \{Ian F.\} and Jennifer Moliterno and McDermott, \{Michael W.\} and Michael Vogelbaum and Mohsen Javadpour and Daniel Fountain and Mathiesen, \{Tiit Illimar\} and Kenneth Aldape and Jill Barnholtz-Sloan and Omar Pathmanaban and Boutros, \{Paul C.\} and Tzannis Alkividias and Fountas, \{Konstantinos N.\} and Walsh, \{Kyle M.\} and Short, \{Susan C.\} and Bruno Carvalho and Maas, \{Sybren L.N.\} and Bos, \{Eelke M.\} and Alper Dincer and Sylvia Kurz and Peter Passlack and Maximilian Deng and Felix Ehret and Mehta, \{Minesh P.\} and Yazmin Odia and Richard Everson and Balogun, \{James A.\} and Clara Lopez and Evan Calabrese and Philipp Karschnia and Nico Teske and Laura Fariselli and Tobias Greve and Christina Arvaniti and Carolina Benjamin and Michael Ivan and Christina Jackson and Sanjeeva Jeyaretna and Daniele Scartoni and Dante Amelio and Joshua Palmer and Jana Ivanidze and Quinn Ostrom and \{Trung Kien\}, Duong and Mark Youngblood and Miguel Millareschavez and Malak Althgafi and Sam Emerson and Michael Weller and Emilie Lerhun and Rafael Mart{\'i}nez-P{\'e}rez and Robert Smee and Raj Mukherjee and Andres Cervio and Clinton Turner and Will Muirhead and Molina, \{Eric Suero\} and Vitowanu Julius and Jiawei Chen and Brij Karmur and Maciej Mrugala and Brian Neth",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2026",

month = feb,

day = "1",

doi = "10.1093/neuonc/noaf237",

language = "English",

volume = "28",

pages = "430--439",

journal = "Neuro-Oncology",

issn = "1522-8517",

number = "2",

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TY - JOUR

T1 - A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

AU - Landry, Alexander P.

AU - Wang, Justin Z.

AU - Patil, Vikas

AU - Ajisebutu, Andrew

AU - Gui, Chloe

AU - Yefet, Leeor S.

AU - Ellenbogen, Yosef

AU - Liu, Jeff

AU - Mamatjan, Yasin

AU - Wei, Qingxia

AU - Singh, Olivia

AU - Mansouri, Sheila

AU - Ehret, Felix

AU - Capper, David

AU - Cohen-Gadol, Aaron

AU - Tabatabai, Ghazaleh

AU - Tatagiba, Marcos

AU - Behling, Felix

AU - Barnholtz-Sloan, Jill

AU - Sloan, Andrew E.

AU - Chambless, Lola B.

AU - Mansouri, Alireza

AU - Makarenko, Serge

AU - Yip, Stephen

AU - Tsang, Derek S.

AU - Gao, Andrew

AU - Aldape, Kenneth

AU - Nassiri, Farshad

AU - Zadeh, Gelareh

AU - Santarius, Thomas

AU - Selman, Warren

AU - Couce, Marta

AU - Sloan, Andrew E.

AU - Brastianos, Priscilla K.

AU - Shih, Helen A.

AU - Linda Bi, W.

AU - Huang, Raymond Y.

AU - Wen, Patrick Y.

AU - Walbert, Tobias

AU - Lee, Ian

AU - Felicella, Michelle

AU - Brodie, Chaya

AU - Malta, Tathiane

AU - Castro, Ana Valeria C.

AU - Noushmehr, Houtan

AU - Snyder, James

AU - Dimeco, Francesco

AU - Saladino, Andrea

AU - Pollo, Bianca

AU - Schichor, Christian

AU - Tonn, Jorg Christian

AU - Kaufmann, Timothy J.

AU - Lachance, Daniel

AU - Giannini, Caterina

AU - Galanis, Evanthia

AU - Raghunathan, Aditya

AU - Hanemann, C. Oliver

AU - Au, Karolyn

AU - Goldbrunner, Roland

AU - Galldiks, Norbert

AU - Timmer, Marco

AU - Ole Schimdt, Nils

AU - Herold-Mende, Christel

AU - Sahm, Felix

AU - Jungk, Christine

AU - Jungwirth, Gerhard

AU - Von Deimling, Andreas

AU - Jenkinson, Michael D.

AU - Millward, Christopher P.

AU - Islim, Abdurrahman I.

AU - Drummond, Katharine

AU - Morokoff, Andrew

AU - Tabatabai, Ghazaleh

AU - Behling, Felix

AU - Renovanz, Mirjam

AU - Tatagiba, Marcos

AU - Santacroce, Antonio

AU - La Fougere, Christian

AU - Schittenhelm, Jens

AU - Raleigh, David R.

AU - Perry, Arie

AU - Butowski, Nicholas

AU - Westphal, Manfred

AU - Lamszus, Katrin

AU - Ricklefs, Franz

AU - Mawrin, Christian

AU - Horbinski, Craig M.

AU - Ng, Ho Keung

AU - Snuderl, Matija

AU - Kurz, Sylvia

AU - Sulman, Erik P.

AU - Zada, Gabriel

AU - Cohen-Gadol, Aaron

AU - Yip, Stephen

AU - Makarenko, Serge

AU - Zherebitskiy, Viktor

AU - Hnenny, Luke

AU - Dunn, Ian F.

AU - Moliterno, Jennifer

AU - McDermott, Michael W.

AU - Vogelbaum, Michael

AU - Javadpour, Mohsen

AU - Fountain, Daniel

AU - Mathiesen, Tiit Illimar

AU - Aldape, Kenneth

AU - Barnholtz-Sloan, Jill

AU - Pathmanaban, Omar

AU - Boutros, Paul C.

AU - Alkividias, Tzannis

AU - Fountas, Konstantinos N.

AU - Walsh, Kyle M.

AU - Short, Susan C.

AU - Carvalho, Bruno

AU - Maas, Sybren L.N.

AU - Bos, Eelke M.

AU - Dincer, Alper

AU - Kurz, Sylvia

AU - Passlack, Peter

AU - Deng, Maximilian

AU - Ehret, Felix

AU - Mehta, Minesh P.

AU - Odia, Yazmin

AU - Everson, Richard

AU - Balogun, James A.

AU - Lopez, Clara

AU - Calabrese, Evan

AU - Karschnia, Philipp

AU - Teske, Nico

AU - Fariselli, Laura

AU - Greve, Tobias

AU - Arvaniti, Christina

AU - Benjamin, Carolina

AU - Ivan, Michael

AU - Jackson, Christina

AU - Jeyaretna, Sanjeeva

AU - Scartoni, Daniele

AU - Amelio, Dante

AU - Palmer, Joshua

AU - Ivanidze, Jana

AU - Ostrom, Quinn

AU - Trung Kien, Duong

AU - Youngblood, Mark

AU - Millareschavez, Miguel

AU - Althgafi, Malak

AU - Emerson, Sam

AU - Weller, Michael

AU - Lerhun, Emilie

AU - Martínez-Pérez, Rafael

AU - Smee, Robert

AU - Mukherjee, Raj

AU - Cervio, Andres

AU - Turner, Clinton

AU - Muirhead, Will

AU - Molina, Eric Suero

AU - Julius, Vitowanu

AU - Chen, Jiawei

AU - Karmur, Brij

AU - Mrugala, Maciej

AU - Neth, Brian

PY - 2026/2/1

Y1 - 2026/2/1

KW - clinical recommendations

KW - DNA methylation

KW - meningioma

KW - neuro-oncology

KW - outcome biomarker

UR - https://www.scopus.com/pages/publications/105032787416

UR - https://www.scopus.com/pages/publications/105032787416#tab=citedBy

U2 - 10.1093/neuonc/noaf237

DO - 10.1093/neuonc/noaf237

M3 - Article

C2 - 41259653

AN - SCOPUS:105032787416

SN - 1522-8517

VL - 28

SP - 430

EP - 439

JO - Neuro-Oncology

JF - Neuro-Oncology

IS - 2

ER -

A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma

ASJC Scopus Subject Areas

Keywords

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