A brave new framework for glioma drug development

Kelly M Hotchkiss; Philipp Karschnia; Karisa C Schreck; Marjolein Geurts; Timothy F Cloughesy; Jason Huse; Elizabeth S Duke; Justin Lathia; David M Ashley; Edjah K Nduom; Georgina Long; Kirit Singh; Anthony Chalmers; Manmeet S Ahluwalia; Amy Heimberger; Stephen Bagley; Tomoki Todo; Roel Verhaak; Patrick D Kelly; Shawn Hervey-Jumper; John de Groot; Anoop Patel; Peter Fecci; Ian Parney; Victoria Wykes; Colin Watts; Terry C Burns; Nader Sanai; Matthias Preusser; Joerg Christian Tonn; Katharine J Drummond; Michael Platten; Sunit Das; Kirk Tanner; Michael A Vogelbaum; Michael Weller; James R Whittle; Mitchel S Berger; Mustafa Khasraw

doi:10.1016/S1470-2045(24)00190-6

A brave new framework for glioma drug development

Kelly M Hotchkiss
, Philipp Karschnia
, Karisa C Schreck
, Marjolein Geurts
, Timothy F Cloughesy
, Jason Huse
, Elizabeth S Duke
, Justin Lathia
, David M Ashley
, Edjah K Nduom
, Georgina Long
, Kirit Singh
, Anthony Chalmers
, Manmeet S Ahluwalia
, Amy Heimberger
, Stephen Bagley
, Tomoki Todo
, Roel Verhaak
, Patrick D Kelly
, Shawn Hervey-Jumper

John de Groot, Anoop Patel, Peter Fecci, Ian Parney, Victoria Wykes, Colin Watts, Terry C Burns, Nader Sanai, Matthias Preusser, Joerg Christian Tonn, Katharine J Drummond, Michael Platten, Sunit Das, Kirk Tanner, Michael A Vogelbaum, Michael Weller, James R Whittle, Mitchel S Berger, Mustafa Khasraw

Research output: Contribution to journal › Review article › peer-review

Abstract

Patients with brain tumours are motivated to participate in clinical trials involving repeat tissue sampling. Normalising the use of neoadjuvant and staged surgical trials necessitates collaboration among patients, regulatory agencies, and researchers. Initial and repetitive tissue sampling plays a crucial role in enhancing our understanding of resistance mechanisms and vulnerabilities in brain tumour therapy. Standardising biopsy techniques and ensuring technical uniformity across institutions are vital for effective interinstitutional collaboration. Although liquid biopsy technologies hold promise, they are not yet ready to replace tissue analysis. Clear communication about the risks and benefits of biopsies is essential, particularly regarding potential postoperative deficits. Changes in mindset and neurosurgical culture are imperative to achieve much needed breakthroughs in the development of new, effective therapies for brain tumours.

Original language	English
Pages (from-to)	e512-e519
Journal	The Lancet Oncology
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/S1470-2045(24)00190-6
State	Published - Oct 2024

Keywords

Humans
Brain Neoplasms/drug therapy
Glioma/drug therapy
Drug Development
Antineoplastic Agents/therapeutic use

Access to Document

10.1016/S1470-2045(24)00190-6

Cite this

Hotchkiss, K. M., Karschnia, P., Schreck, K. C., Geurts, M., Cloughesy, T. F., Huse, J., Duke, E. S., Lathia, J., Ashley, D. M., Nduom, E. K., Long, G., Singh, K., Chalmers, A., Ahluwalia, M. S., Heimberger, A., Bagley, S., Todo, T., Verhaak, R., Kelly, P. D., ... Khasraw, M. (2024). A brave new framework for glioma drug development. The Lancet Oncology, 25(10), e512-e519. https://doi.org/10.1016/S1470-2045(24)00190-6

Hotchkiss, KM, Karschnia, P, Schreck, KC, Geurts, M, Cloughesy, TF, Huse, J, Duke, ES, Lathia, J, Ashley, DM, Nduom, EK, Long, G, Singh, K, Chalmers, A, Ahluwalia, MS, Heimberger, A, Bagley, S, Todo, T, Verhaak, R, Kelly, PD, Hervey-Jumper, S, de Groot, J, Patel, A, Fecci, P, Parney, I, Wykes, V, Watts, C, Burns, TC, Sanai, N, Preusser, M, Tonn, JC, Drummond, KJ, Platten, M, Das, S, Tanner, K, Vogelbaum, MA, Weller, M, Whittle, JR, Berger, MS & Khasraw, M 2024, 'A brave new framework for glioma drug development', The Lancet Oncology, vol. 25, no. 10, pp. e512-e519. https://doi.org/10.1016/S1470-2045(24)00190-6

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abstract = "Patients with brain tumours are motivated to participate in clinical trials involving repeat tissue sampling. Normalising the use of neoadjuvant and staged surgical trials necessitates collaboration among patients, regulatory agencies, and researchers. Initial and repetitive tissue sampling plays a crucial role in enhancing our understanding of resistance mechanisms and vulnerabilities in brain tumour therapy. Standardising biopsy techniques and ensuring technical uniformity across institutions are vital for effective interinstitutional collaboration. Although liquid biopsy technologies hold promise, they are not yet ready to replace tissue analysis. Clear communication about the risks and benefits of biopsies is essential, particularly regarding potential postoperative deficits. Changes in mindset and neurosurgical culture are imperative to achieve much needed breakthroughs in the development of new, effective therapies for brain tumours.",

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AU - Huse, Jason

AU - Duke, Elizabeth S

AU - Lathia, Justin

AU - Ashley, David M

AU - Nduom, Edjah K

AU - Long, Georgina

AU - Singh, Kirit

AU - Chalmers, Anthony

AU - Ahluwalia, Manmeet S

AU - Heimberger, Amy

AU - Bagley, Stephen

AU - Todo, Tomoki

AU - Verhaak, Roel

AU - Kelly, Patrick D

AU - Hervey-Jumper, Shawn

AU - de Groot, John

AU - Patel, Anoop

AU - Fecci, Peter

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AU - Wykes, Victoria

AU - Watts, Colin

AU - Burns, Terry C

AU - Sanai, Nader

AU - Preusser, Matthias

AU - Tonn, Joerg Christian

AU - Drummond, Katharine J

AU - Platten, Michael

AU - Das, Sunit

AU - Tanner, Kirk

AU - Vogelbaum, Michael A

AU - Weller, Michael

AU - Whittle, James R

AU - Berger, Mitchel S

AU - Khasraw, Mustafa

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AB - Patients with brain tumours are motivated to participate in clinical trials involving repeat tissue sampling. Normalising the use of neoadjuvant and staged surgical trials necessitates collaboration among patients, regulatory agencies, and researchers. Initial and repetitive tissue sampling plays a crucial role in enhancing our understanding of resistance mechanisms and vulnerabilities in brain tumour therapy. Standardising biopsy techniques and ensuring technical uniformity across institutions are vital for effective interinstitutional collaboration. Although liquid biopsy technologies hold promise, they are not yet ready to replace tissue analysis. Clear communication about the risks and benefits of biopsies is essential, particularly regarding potential postoperative deficits. Changes in mindset and neurosurgical culture are imperative to achieve much needed breakthroughs in the development of new, effective therapies for brain tumours.

KW - Humans

KW - Brain Neoplasms/drug therapy

KW - Glioma/drug therapy

KW - Drug Development

KW - Antineoplastic Agents/therapeutic use

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