Research output per year
Research output per year
Personal profile
About
Frank Vrionis, M.D., is the medical director of Marcus Neuroscience Institute, established at Boca Raton Regional Hospital, part of Baptist Health. Dr. Vrionis specializes in treating brain, skull base and spine tumors. He has extensive experience in minimally invasive spine surgery, brain tumor surgery, skull base surgery, vascular neurosurgery and poliovirus treatment of brain tumors.
Prior to joining Marcus Neuroscience Institute in 2016, Dr. Vrionis spent 17 years at the H. Lee Moffitt Cancer Center.
Active in research, Dr. Vrionis described for the first time the presence of cancer stem cells in malignant brain tumors and established through a clinical trial the role of vertebroplasty for spine fractures in cancer patients.
Dr. Vrionis serves as a professor of surgery at the Charles E. Schmidt College of Medicine at Florida Atlantic University.
Dr. Vrionis’ approach to patient care is to treat each patient with love and respect, as he would a member of his own family. When he is not treating patients, he enjoys spending time in nature, farming, traveling, reading about philosophy and skiing.
Related documents
Education/Academic qualification
Department of Neurosurgery, Residency Program - Neurosurgery, Tufts University
1991 → 1997
Semmes-Murphey Clinic and Department of Neurosurgery, Fellowship Program - Skull-base Surgery, University of Tennessee
1995 → 1996
Department of Surgery, Internship, Tufts University
1990 → 1991
Tumor Immunology, Ph.D., Duke University
1986 → 1990
Public Health, M.P.H., Harvard University
1985 → 1986
School of Medicine, Doctor of Medicine, M.D., University of Athens
1977 → 1984
External positions
Professor of Surgery, Florida Atlantic University
Oct 1 2016 → …
Chief of Neurosurgery, H. Lee Moffitt Cancer Center
Jan 1 2011 → Jan 1 2016
Director and Founder, Spine Research Laboratory, H. Lee Moffitt Cancer Center
Jun 1 2009 → Jan 1 2015
Professor, Departments of Oncologic Sciences, University of South Florida
Mar 1 2009 → Jan 1 2016
Director and Founder, Spine Oncology Fellowship Program, H. Lee Moffitt Cancer Center
Jul 1 2007 → Jan 1 2016
Associate Professor of Neurosurgery, Orthopedic Surgery & Oncology, University of South Florida
Jun 1 2003 → Jan 1 2009
Chief of Neurosurgery, James A. Haley Veterans Administration Hospital
Oct 1 1999 → Apr 1 2000
Assistant Professor of Neurosurgery Otolaryngology, Head & Neck Surgery, University of South Florida
Oct 1 1999 → May 1 2003
Neurosurgical Associate, Semmes-Murphey Clinic
Jul 1 1997 → Oct 1 1999
Assistant Professor, Departments of Neurosurgery, Anatomy and Neurobiology, University of Tennessee
Jul 1 1997 → Oct 1 1999
Director and Founder, Human Brain Tumor Research Laboratory, University of Tennessee
Jul 1 1997 → Oct 1 1999
Disciplines
- Medicine and Health Sciences
- Neurosciences
- Neurology
- Surgery
- Neurosurgery
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Advancements, Challenges, and Innovations in Mechanical and Animal Testing of Lumbar Spine Implants
Comella, Z., Kainth, R., Arab, Y., Beaulieu, E., Lin, M., Paul, R., Sharp, R., Cheema, T. S. & Vrionis, F. D., Apr 2026, In: Applied Sciences (Switzerland). 16, 8, 3662.Research output: Contribution to journal › Review article › peer-review
Open Access -
Advances in biomechanical modeling of lumbar spine diseases and tumors: gaps, opportunities, and AI integration
Beaulieu, E., Daffner, M., Obraitis, D., Weston, R., Patel, S., Comella, Z., Lin, M., Biswas, D., Paul, R., Pires, G., Cheema, T. S. & Vrionis, F. D., 2026, In: Frontiers in Bioengineering and Biotechnology. 14, p. 1786433Research output: Contribution to journal › Review article › peer-review
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A Review of Finite Element Analysis in Spine Surgery Decision-Making
Beaulieu, E., Wise, J., Merem, I., Comella, Z., Afsahi, R., Roemer, J., Lin, M., Sharp, R., Cheema, T. S. & Vrionis, F. D., Apr 2026, In: Journal of clinical medicine. 15, 7, 2584.Research output: Contribution to journal › Review article › peer-review
Open Access -
A Review of Motion-Preserving Cervical Spinal Implants and Fusion Constructs
Merem, I., Vasquez, R., Wise, J., Beaulieu, E., Patel, S., Lin, M., Pires, G. & Vrionis, F. D., Feb 2026, In: Bioengineering. 13, 2, 228.Research output: Contribution to journal › Review article › peer-review
Open Access -
A Review of Synthetic Bone Grafts in Lumbar Interbody Fusion
Wise, J., Merem, I., Wrubluski, D., Zhang, X., Weston, R., Shi, M., Lin, M. & Vrionis, F. D., Mar 2026, In: Bioengineering. 13, 3, 262.Research output: Contribution to journal › Review article › peer-review
Open Access
Activities
- 11 Membership of network
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American Academy of Spine Physicians (External organization)
Vrionis, F. (Member)
Jan 1 2007 → Jan 1 2009Activity: Membership › Membership of network
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AO North America (External organization)
Vrionis, F. (Member)
Jan 1 2005 → Jan 1 2016Activity: Membership › Membership of network
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Florida Neurosurgical Society (External organization)
Vrionis, F. (Member)
Jan 1 2001 → Jan 1 2007Activity: Membership › Membership of network
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North American Skull Base Society (External organization)
Vrionis, F. (Member)
Jan 1 1999 → Jan 1 2009Activity: Membership › Membership of network
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American Cancer Research Association (External organization)
Vrionis, F. (Member)
Jan 1 1999 → Jan 1 2005Activity: Membership › Membership of network
Prizes
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01/2007 United Health Premium Quality and Efficiency of Care (two star) Designation for Spine Surgery
Vrionis, F. (Recipient), 2007
Prize: Prize (including medals and awards)
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02/2009 Certificate of Appreciation 2nd Annual Perioperative Nursing Multidisciplinary Conference H. Lee Moffitt Cancer Center
Vrionis, F. (Recipient), 2009
Prize: Prize (including medals and awards)
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02/2013 Physician of the Year H. Lee Moffitt Cancer Center
Vrionis, F. (Recipient), 2013
Prize: Prize (including medals and awards)
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05/1993 Brain Tumor Society Award, “Retroviral vector gene therapy in a rat model of neoplastic meningitis”
Vrionis, F. (Recipient), 1993
Prize: Prize (including medals and awards)
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09/1994 Brain Tumor Society Aware, “Mechanisms related to the bystander cytocidal effect and the role of the bystander effect in the treatment of meningeal neoplasia”
Vrionis, F. (Recipient), 1994
Prize: Prize (including medals and awards)